摘要
质子泵抑制剂(PPI)能够特异性地作用于胃黏膜壁细胞,抑制壁细胞中H+-K+-ATP酶的活性,对各种原因引起的胃酸分泌具有强而持久的抑制作用。PPI广泛应用于消化性溃疡、胃食管反流病、幽门螺杆菌感染、消化道出血等疾病的治疗,以及用于预防应激性急性胃黏膜损伤。但是,近年来PPI口服制剂的过度使用、不正确的使用方法、不合理的联合用药及药物相互作用导致的安全性及不规范使用问题较为突出。本文回顾了PPI口服制剂临床应用的相关文献,对口服制剂的的分类、作用特点、临床使用方法、药物相互作用及药品不良反应等进行了综述分析,以促进PPI口服制剂的安全合理使用。
Proton pump inhibitors (PPI) can inhibit H+-K+-ATP enzyme activity in the cell wall through specifically acting on parietal cells of the gastric mucosa, and have strong and long-lasting inhibition on secretion of gastric acid due to various causes. PPI are widely used in peptic ulcers, gastroesophageal re-flux disease, Helicobacter pylori infection, gastrointestinal bleeding and prevention of stress of acute gastric mucosal injury. However, in recent years, excessive use of oral PPI, improper method of use, irrational combined use of drugs and drug interactions lead to prominent problems of safety and rationality. This pa-per reviews the literatures related to PPI oral preparations on their classification, characteristics, clinical applications, drug interactions and adverse drug reactions, in order to promote safe and rational use of PPI.
出处
《药学与临床研究》
2015年第4期376-379,共4页
Pharmaceutical and Clinical Research
关键词
口服质子泵抑制剂
临床应用
安全性评价
Oral proton pump inhibitor preparation
Clinical application
Evaluation of safety
