摘要
目的分析青中年缺血性脑卒中患者颈动脉彩色多普勒超声特点,并探讨与其相关的危险因素。方法我院神经内科的青中年缺血性脑卒中病患者156例,选择性别和年龄匹配的健康青中年145例作为对照组,同时完成颈动脉血管超声检查和血液学检查指标,分析两组入选者颈动脉超声特点。按超声检测结果将156例脑卒中患者分为稳定斑块组和不稳定斑块组,进行相关危险因素分析。结果脑卒中组颈动脉粥样硬化斑块检出率、不稳定斑块发生率、颈动脉狭窄率、血管壁内-中膜厚度（intima-media thickness,IMT）及斑块Crouse积分均明显高于健康对照组（P〈0.01）。在各相关危险因素中,年龄、男性、吸烟史、血糖、低密度脂蛋白胆固醇（LDL-C）、高同型半胱氨酸血症（Hcy）、高尿酸血症在不稳定斑块组与稳定斑块组间差异有统计学意义（P〈0.05）,其他各项指标两组之间差异均无统计学意义（P〉0.05）。年龄（OR=1.846,95%CI=1.293~2.636,P〈0.01）、吸烟史（OR=1.277,95%CI=1.221~1.675,P〈0.05）、高同型半胱氨酸血症（OR=1.845,95%CI=1.040~3.273,P〈0.05）、高尿酸血症（OR=1.033,95%CI=1.010~1.057,P〈0.01）是不稳定斑块的独立危险因素。结论颈动脉粥样硬化斑块与中青年缺血性脑卒中发生密切相关,IMT增加、斑块检出、颈动脉狭窄及不稳定斑块等颈动脉超声特征性改变对中青年缺血性脑卒中有提示意义。年龄、吸烟、高尿酸血症是青中年缺血性脑卒中患者不稳定斑块的独立危险因素。
Objective To analyze the characteristics of carotid artery ultrasonography and the related risk factors in young and middle-aged patients with cerebral stroke.Methods 156 young and middle-aged patients with cerebral stroke hospitalized in department of neurology and 145 normal control subjects were examined with both color Doppler ultrasonography and fasting blood check.156 patients with cerebral stroke were divided into soft plaque group,hard plaque group.The corresponding risk factors were observed and detected.Results The positive rates of carotid artery atherosclerotic,the rates of incidence of unstable plaques,the rates of carotid artery stenosis,carotid intima-media thickness（IMT）and Crouse points in cerebral in fraction patients significantly increased as compared with normal control subjects（P 0.01）.Age, male,smoking status,diabetes mellitus,low-density lipoprotein cholesterol,high homocysteine levels,hyperuricemia between unstable carotid plaque group and stable carotid plaque group showed significant difference（P 0.05）,however,other risk factors had no significant difference（P 0.05）.Age（OR =1.846,95%CI =1.293-2.636,P 0.01）,smoking status（OR =1.277,95%CI =1.221-1.675,P 0.05）,high homocysteine levels（OR =1.845,95%CI =1.040-3.273,P 0.05）,hyperuricemia（OR =1.033,95%CI =1.010-1.057,P 0.01）were determined as the independent risk factor of unstable carotid plaque.Conclusion Cerebral infarction in young and middle-aged patients is closely related to atherosclerosis of carotid artery.Age,smoking status,high homocysteine levels,hyperuricemia are independent risk factors of unstable carotid plaque.
出处
《临床荟萃》
CAS
2015年第10期1140-1143,共4页
Clinical Focus
关键词
脑血管意外
颈动脉狭窄
超声检查
多普勒
彩色
危险因素
cerebrovascular accident
carotid stenosis
ultrasonography
Doppler
color
risk factors
