摘要
目的：观察手术后给予丹参治疗对重度颅脑损伤患者的临床疗效及患者后遗症改善情况。方法：60例重度颅脑损伤患者按随机数字表法分为对照组和治疗组,各30例。对照组患者根据具体情况行开颅血肿清除术或去骨瓣减压术后进行常规及对症治疗,治疗组患者在对照组基础上,于术后3~5 d无出血倾向后给予丹参注射液20 ml/d静脉滴注,连续治疗7~10 d,然后改用复方丹参滴丸（10丸/次,3次/d）继续口服1个月。比较两组患者术后不同时间的格拉斯哥昏迷评分（GCS）、格拉斯哥预后评分（GOS）、颅内压、头颅CT、血浆内皮素（ET）和C反应蛋白（CRP）水平的变化;复查3个月后患者后遗症发生情况。结果：术后给予丹参治疗可明显增加颅脑损伤患者GCS评分和GOS评分,降低患者颅内压水平和脑水肿程度,且治疗组患者临床症状改善速度显著快于对照组,差异有统计学意义（P〈0.05或P〈0.01）。术后给予丹参治疗可呈时间依赖性地降低颅脑损伤患者血浆ET和CRP水平,且治疗组降低速度显著快于对照组,差异有统计学意义（P〈0.05或P〈0.01）。术后治疗组患者后遗症改善总有效率为93.3%,显著高于对照组的76.7%,差异有统计学意义（P〈0.05）。结论：重度颅脑损伤患者手术后给予丹参治疗可促进临床症状的改善,减少并发症的发生,提高预后,上述作用可能与降低患者血浆ET和CRP水平有关。
OBJECTIVE： To observe the clinical efficacy and sequela of Salvia miltiorrhiza treatment for severe craniocere- bral injury patients after operation. METHODS： 60 severe craniocerebral injury patients were randomly divided into control group and treatment group with 30 cases in each group. Control group was given routine and symptomatic treatment after clearance of hematoma by craniotomy or decompressive craniectomy according to the patient＇s condition; treatment group was additionally giv- en intravenous injection of Danshen injection 20 ml/d for 7-10 days 3-5 days after operation without hemorrhagic tendency, on the basis of control group, and then given Compound danshen dropping pills instead （10 pills/time, 3 times/d） for one month. GCS score, GOS score, intracranial pressure and brain CT, the levels of ET and CRP were compared between 2 groups after op- eration. The occurrence of sequelae were evaluated 3 months after operation. RESULTS： After the operation, S. miltiorrhiza treat- ment could increase GCS score and GOS score, reduced intracranial pressure and brain edema of craniocerebral injury patients, and the improvement of clinical symptoms in treatment group was significantly faster than in control group, with statistical signifi- cance （P〈0.05 or P〈0.01）. The postoperative S. miltiorrhiza treatment could decrease the levels of ET and CRP in patients with craniocerebral injury in the time-dependent manner, the decreased of treatment group was significantly faster than that of control group, with statistical significance （P〈0.05 or P〈0.01）. The effective of postoperative sequelae improvement was 93.3% in treatment group, which was significantly higher than that of control group （76.7%）, with statistical significance （P〈0.05）. CON- CLUSIONS： Postoperative S. miltiorrhiza treatment can improve the clinical symptoms of severe craniocerebral injury patients, re- duce the incidence of complication and improve the prognosis. The effect may be related to the decrease of plasma ET and CRP levels.
出处
《中国药房》
CAS
北大核心
2015年第32期4537-4540,共4页
China Pharmacy
关键词
丹参
重度颅脑损伤
手术后
内皮素
C反应蛋白
Salvia miltiorrhiza
Severe craniocerebral injury
Postoperative
ET
CRP
