期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

冠心病不稳定心绞痛治疗前后血清趋化因子CXCL 16检测的临床意义 被引量：5

在线阅读 下载PDF
导出
摘要 目的探讨冠心病不稳定心绞痛治疗前后血清CXCL 16水平的变化及意义。方法应用酶联免疫吸附法(ELISA)对51例冠心病不稳定心绞痛患者进行了治疗前后血清CXCL 16水平检测,并以35名正常健康人作比较。结果冠心病不稳定心绞痛患者在治疗前血清CXCL 16水平显著高于正常人组,差异有统计学意义(P<0.01),经治疗6个月后,与治疗前有明显差异并与正常人比较,差异有统计学意义(P<0.05)。结论趋化因子CXCL 16在冠心病不稳定心绞痛的发病机制中具有重要的作用,有一定的临床价值。
作者 祝盛善 王庆春 胡坚
机构地区 江苏省连云港市中医院检验科
出处 《临床合理用药杂志》 2015年第8期88-89,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 冠心病不稳定心绞痛 趋化因子 CXCL 16
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

  • 1李刚,周兴文.新的冠心病危险因素[J].心血管病学进展,2005,26(3):266-271. 被引量：24
  • 2Galkina E, Harry B L, Ludwing A, et al. CXCR6 promotes atherosclerosis by srpporting T-cell homing, interferon-gamma production, and macro-phage accumulation in the aortic wall [ J ]. Circulation,2007,116 (16) : 1801 -1811.
  • 3Tabata S, Kadowaki N, Kitawaki T, et al. Distribution and kinetics of SR- PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4 + T cells[J]. J Leukoc Biol,2005,77(5) :777 -786.
  • 4Yi GW,Zeng QT. Circulating CXCL16 is related to the severity of coro- nary artery stenosis [ J ]. Arch Med Res, 2008,39 ( 5 ) : 531 - 550.
  • 5Lehrke M, Millington SC, Leftereva M, et al. CXCL16 is a marker of INF- ~/lammation, atheresclerosis, and acute corenary syndromes in humans [ J].J Am Cell Cardiol,2007,49(4) :442 -449.
  • 6Aslanian AM, Charu IF. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atheresclerosis [ J ]. Circulation, 2006,114(6) :583 -590.
  • 7Yamauchi R, Tanaka M, Kume N, et al. Upregulation of SR-PSOX/CX- CL16 and recruitment of CD8 + T cells in cardiac valves during inflam- matory valvular heart disease [ J ]. Arterioscler Thromb Vasc Biol,2004, 24(2) :282 -287.
  • 8Wuttge DM, Zhou X, Sheikine Y, et al. CXCL16/SR-PSOX is an inter- feron-gamma-regulated chemokine and scavenger receptor expressed in atherescleretic lesions [ J ]. Arterioscler Thremb Vasc Biel,2004,24 (4) : 750 - 755.
  • 9Tenger C, Sundborger A, Jawien J;et al. IL-18 accelerates atheroseleresis accompanied by elevation of IFN-gamma and CXCLI6 expression inde- pendently of T cells [ J ]. Arterioscler Thromb Vase Bid, 2005,25 ( 4 ) : 791 - 796.
  • 10Shimaoka T, Nakayama T, Kume i'q, et al. Cutting edge : SR-PSOX/CXC chemokine ligand 16 mediates bacterial phagocytosis by APCs through its chemokine domain[ J]. J Immunol,2003,171 (4) :1647 -1651.

二级参考文献43

  • 1Barlic J,Murphy PM.Chemokine regulation of atherosclerosis.J Leukoc Biol,2007,82:226-236.
  • 2Wilbanks A,Zondlo SC,Murphy K,et al.Expression cloning of the STRL33/BONZO/TYMSTR ligand reveals elements of CC,CXC,and CX3C chemokines.J Immunol,2001,166:5145-5154.
  • 3Matloubian M,David A,Engel S,et al.A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo,Nat Immunol,2000,1:298-304.
  • 4Shimaoka T,Nakayama T,Fukumoto N,et al.Cell surface-an-chored SR-PSOx/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells,J Leukoc Biol,2004,75:267-274.
  • 5Bots ML,Hoes AW,Koodstaal PJ,et al.Common carotid intima-media thickness and risk Of stroke and myocardial infarctiOn:the Rotterdam Study.CirculatiOn,1997,96:1432-1437.
  • 6Libby P,Ridker PM,Maseri A.Inflammation and atherosclerosis,Circulation,2002,105:1135-143.
  • 7Chandraskar B,Bysani S,Mummidi S.cxcl16 signals via Gi,phosphatidylinositol 3-kinase,Akt,I Kappa B kinase,and nuclear factor-kappa Band induces cell-cell adhesion and daortics smooth muscle cell proliferation.JBiol Chem,2004,279:3188-196.
  • 8Gough Pj,Garton KJ,Wille Pt,et al.A disintegriand metalloproteinase 10-mediated cleavage and shedding regulates the cells surface expression of CXC chemokine ligand 16.J Immunol,2004,172:3678-685.
  • 9Libby P,Ridker PM,Maseri A. Inflammation and atherosclerosis[J]. Circulation,2002,105:1135-1143.
  • 10Ross R. Atherosclerosis-an inflammatory disease[J]. N Engl J Med,1999,340(2):115-126.

共引文献29

同被引文献65

二级引证文献50

临床合理用药杂志
2015年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部