摘要
目的评价我国RA患者抑郁的患病情况。方法检索Cochrane图书馆、Medline、EMbase、中国期刊全文数据库（CNKI）、中国生物医学数据库（CBM）、中文科技期刊数据库（VIP）及万方数据库中关于我国成人RA患者抑郁的相关文献，进行文献质量评价后，应用R3．2．0软件进行Meta分析。结果共纳入文献25篇，样本总量4830例，抑郁患者2712例，抑郁患病率经分析合并效应量为44．7％[95％CI（37．5％，52．0％）]，与纳入研究中抑郁率中位数43．0％接近，高于全球平均水平38．8％[95％C1（34．0％，43．0％）]；其中8篇报道了轻度抑郁率和中重度抑郁率，样本含量1028例，轻度抑郁311例，中重度219例；抑郁患病率分别为30．2％[95％C1（22．1％，40．0％）]，16．5％[95％CI（9．6％，26．9％）]。亚组分析结果显示女性RA患者抑郁率高于男性，中西部地区抑郁率高于东部地区，使用老年抑郁量表检出的抑郁率高于其他量表检出率。敏感性分析显示，合并效应结果具有较好的稳定性和可靠性。结论我国RA患者抑郁率高达44．7％，应引起医护人员的高度重视。
Objective To evaluate the rate of depression in adult rheumatoid arthritis （RA） patients in China. Methods Literature search was conducted to collect studies on the prevalence of depression in adult RA patients in Coehrane library, Medline, EMbase, China National Knowledge Internet （CNKI）,China Biology Medicine （CBM）, Chinese science ＆ technology journal database （VIP） and Wanfang database. Data were analyzed by R 3.2.0 software after evaluating all data. Results A total of 25 studies, including a total size of 4 830 and 2 712 patients of depression, were eligible for inclusion in the review. The prevalence of depression by analyzing the effect size was 44.7% [95%CI （37.5%, 52.0%）], which was close to the median of 43.0% from all studies included and higher than the global rate 38.8% [95%CI （34%, 43%）]. Eight studies, including the sample size of 1 028 cases, 311 cases of mild depressive disorders and 219 cases of moderate or severe depressive disorders, reported the prevalence levels of 30.2% [30.2%CI （22.1%, 40.0%）] and 16.5% [95%CI （9.6%,26.9%）], respectively. Subgroup analysis showed that the depression rate of female RA patients was higher than male, the depression rate in the central and western areas were higher than that of the eastern region, the prevalence level estimated by the Geriatric Depression Scale （GDS） was higher than estimated by other tools. Sensitivity analysis showed that the pooled effect size had good stability and reliability. Conclusion The prevalence rate of depression in adult RA patients is 44.7%, suggesting that medical staff should pay much attention to depression in adult RA patients.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2015年第10期662-668,共7页
Chinese Journal of Rheumatology
