摘要
目的探讨一期后路经椎间孔入路病灶清除、椎体间非结构性植骨、椎弓根钉棒内固定术治疗单节段腰椎结核的可行性和安全性。方法 2010年1月-2013年4月采用一期后路经椎间孔入路病灶清除、椎体间非结构性植骨、椎弓根钉棒内固定治疗单节段腰椎结核患者21例,其中男9例,女12例,平均年龄49.1岁,合并神经功能损害者8例。术前CT和MRI提示腰椎病灶以单侧为主,均存在明显的骨质破坏。术前给予抗结核药物治疗2~3周。术中椎体间植骨采用局部骨颗粒和自体髂后松质骨颗粒。术后定期复查腰椎X线片及CT,以评价植骨融合情况和腰椎生理弧度变化。记录患者术前、术后及末次随访时VAS评分、红细胞沉降率（ESR）、C反应蛋白变化。结果术后所有患者均获得随访,随访时间25.3±4.2个月。21例患者手术时间为157±39min,手术失血量为470±143ml。术后椎体间植骨融合率为95.2%,融合时间6.1±2.5个月,神经功能改善率100%,无严重并发症发生。术前、术后腰椎前凸Cobb角分别为21.4°±5.7°、33.6°±3.1°,末次随访时为31.3°±2.7°。术前、术后VAS评分分别为7.8±2.6、2.4±1.7,末次随访时为0.9±0.7。术后3个月ESR、C反应蛋白均明显下降,术后6个月恢复至正常水平。结论一期后路经椎间孔入路病灶清除、椎体间非结构性植骨、椎弓根钉棒内固定治疗单节段腰椎结核安全、有效。
Objective To evaluate the efficacy and safety of pedicle screw-rod internal fixation after one-stage posterior transforaminal lesion debridement and non-structural bone grafting in the treatment of tuberculosis of mono-segmental lumbar vertebra. Methods From January 2010 to April 2013, 21 patients（9 males and 12 females with an average age of 49.1 years） with mono-segmental tuberculosis of lumbar vertebra underwent surgery in our hospital were included. Eight patients had neurological deficit. The focus of tuberculosis was located on one side of the vertebral body, and all the patients had obvious signs of bone destruction on CT and MRI. All the patients were given anti-tuberculosis chemotherapy for 2-3 weeks before surgery. The local bone chips and autologous iliac cancellous bone were used as the intervertebral bone graft. Postoperative plain radiographs and CT were obtained to evaluate the fusion rate and degree of lumbar lordosis. The visual analogue scale score（VAS）, erythrocyte sedimentation rate（ESR）, and C-reactive protein（CRP） before and after operation, and at final follow-up date were recorded. Results All the patients were followed up for 25.3±4.2 months. The mean operation time was 157±39 minutes, and the average blood loss was 470±143ml. The fusion rate of the interbody bone graft was 95.2%, with an average fusion period of 6.1±2.5 months. The neurological function was improved by 100%, and no severe complication or neurological injury occured. The preoperative and postoperative lordosis angles of the lumbar spine were 21.4°±5.7° and 33.6°±3.1°, respectively, and it was 31.3°±2.7° at the final follow up. The preoperative and postoperative VAS scores were 7.8±2.6 and 2.4±1.7 respectively, and it was 0.9±0.7 at the final follow up. The ESR and CRP were significantly decreased 3 months after surgery, and they became normal at 6 months. Conclusion Pedicle screw-rod internal fixation after one-stage posterior transforaminal lesion debridement and non-structural bone grafting is effective and safe in treating mono-segmental lumbar tuberculosis.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2015年第11期938-942,共5页
Medical Journal of Chinese People's Liberation Army
基金
江西省科技厅科技计划项目(20122BBG70121-2)~~
关键词
经椎间孔入路
结核
脊柱
腰椎
植骨
内固定器
transforaminal approach
tuberculosis
spinal
lumbar vertebrae
bone graft
internal fixators
