摘要
目的:利用改良的basic and specific(BASP)分类分级法探讨雄激素性秃发(AGA)家族遗传史与其秃发类型、发病年龄、秃发严重程度及疗效的关系。方法:收集2013年1月—2014年12月来南京医科大学第一附属医院皮肤科毛发疾病门诊就诊的AGA患者。根据患者脱发情况进行改良的BASP分型,按照其脱发家族史进行分组,利用统计软件SPSS 22.0进行分析。结果:男性AGA患者家族史阳性率明显高于女性。AGA患者的基本秃发类型在父子间具有相关性。有AGA家族史的男性患者比无家族史患者在相同发病时间内脱发更严重,而女性患者脱发严重程度受家族史影响小。有AGA家族史患者平均发病年龄比无家族史患者早。AGA家族史对于治疗脱发疗效无影响。结论:有AGA家族史患者发病年龄早,脱发严重程度加重,且不同族系、不同亲缘级别的家族史对于患者脱发类型、严重程度的影响也不同,不同性别的患者受家族史的影响也有差别。
Objective： To explore whether the family history of androgenetic alopecia（AGA） is related with the pattern of hair loss, age of onset, severity of hair loss and therapeutic effect by using the modified basic and speeific（BASP） classifi- cation. Methods： AGA outpatients were collected from January 2013 to December 2014 in the hair disease clinic of the First Affiliated Hospital of Nanjing Medical University. The patients were classified by the status of alopecia with modified BASP classification and grouped by the family history. All results were analyzed by the statistical software SPSS 22.0. Results： The positive rate of AGA family history in the male patients was higher than that in the female patients significantly. Basic pat- tern of alopecia had a significant genetic predisposition between father and son. The severity of AGA in the male patients with family history was more serious than those without family history, while the influence of family history on the hair loss was less in the female patients. The age of onset of the patients with family history was younger than those without family history. The family history had no effect on the therapeutic effect of AGA. Conclusion： The earlier the onset of the disease in the patient with family history, the more severe is the hair loss. The effects of the family history of different families and different levels of kinship on the pattern of alopecia and severity of hair loss are different. The influence of the family histo- ry on different genders is also different.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2015年第12期770-773,共4页
Journal of Clinical Dermatology
