摘要
目的观察不同的随访密度对结直肠癌(CRC)患者术后生存情况的影响。方法采用前瞻性队列研究方法,对2007年1月至2009年12月间符合纳入标准的172例CRC患者术后随访5年,将完成随访任务70%以上的患者设为密集随访组(104例),完成随访任务70%以下的患者设为对照组(68例),采用Kaplan-Meier法并绘制生存曲线分析两组患者术后5年生存情况及复发后5年生存情况。结果密集随访组在术后5年生存率(76.9%)、中位生存时间(53.5个月)及复发后中位生存时间(39.6个月)均较对照组有优势(均P<0.05),两组患者术后5年复发率(分别为31.7%、20.6%)及复发后生存率(分别为30.3%、14.3%)比较均无统计学差异(均P>0.05)。密集随访组Ⅱ、Ⅲ期CRC患者术后5年中位生存时间(分别为60.0个月、42.1个月)显著长于对照组Ⅱ、Ⅲ期CRC患者(分别为44.6个月、37.8个月),差异均有统计学意义(均P<0.05)。结论密集的随访能改善CRC患者术后的生存状况。
Objective To investigate the association of follow-up density after radical surgery with the survival of pa- tients with colorectal cancer （CRC）. Methods One hundred and seventy two CRC patients undergoing radical resection from 2007 to 2009 were included in a 5-year follow-up surveillance program. Among them 104 patients attended 70% appointments （intensive follow-up group）, the rest 68 patients attended 〈70% appointments （control group）. The 5-year overall survival after radical resection and 5-year survival after recurrence were analyzed by Kaplan-Meier survival curve and compared between two groups. Results The 5-year overall survival rate （76.9%） , median survival time （53.49 months） and median survival time after recurrence （39.61 months） in intensive follow-up group were significantly higher than those in control group （all P〈0.05）. There was no difference in recurrence rate （31.7% vs. 20.6%, P 〉0.05） and 5-year survival rate after recurrence （30.3% vs. 14.3%, P 〉0.05） between two groups. The median survival time of stage II tumors （60 months） and III tumors （42.08 months） in inten- sive follow-up group was higher than that of stage II tumors （44.57months） and III tumors（37.80） in control group（both P〈 0.05）. Conclusion Intensive follow-up after radical surgery for colorectal cancer can improves survival of patients.
出处
《浙江医学》
CAS
2015年第20期1664-1667,共4页
Zhejiang Medical Journal
关键词
结直肠癌
随访
生存分析
队列研究
Colorectal cancer Follow-up Survival analysis Cohort study
