摘要
目的综合评价胆红素与肾病综合征(nephrotic syndrome,NS)的关系,为诊治NS提供依据。方法通过检索Pub Med,CNKI、维普数据、万方数据等数据库,收集国内外公开发表的有关胆红素与肾病综合征关系的病例对照研究,按纳入和剔除标准筛选文献,提取数据。采用Stata12.0软件进行Meta分析。结果共纳入7个研究,798例患者。Meta分析结果显示,肾病综合征组胆红素水平低于对照组,其差异有统计学意义[MD=-5.86,95%CI(-6.95,-4.77);Z=10.54,P<0.01]。结论低水平的胆红素水平与NS密切相关,胆红素水平有可能可作为NS的实验室诊断参考指标。
Objective To investigate the relationship between serum bilirubin levels and nephritic syndrome.Methods The PUBMED,CNKI,VIP and other databases were searched to retrieve original studies on serum bilirubin and nephritic syndrome. The research data based on quality assessment were extracted to carry out Meta analysis with Stata 12. 0 software. Results 7 case-control studies with 798 patients were enrolled,and statistics analysis results showed significant difference among those studies [MD =-5. 86,95% CI（-6. 95,-4. 77） ] with marked general effect test（ Z = 10. 54,p〈 0. 01）. The results indicated that bilirubin had great clinical importance in the diagnosis of nephritic syndrome. Conclusion The low level of serum bilirubin might be closely correlated with nephritic syndrome,and the serum bilirubin may be used as a laboratory diagnosis reference index for nephritic syndrome.
出处
《标记免疫分析与临床》
CAS
2015年第11期1133-1135,共3页
Labeled Immunoassays and Clinical Medicine
