摘要
目的：探讨传统西药治疗基础上联合使用中药对早期糖尿病肾病（DN）患者肾功能和生活质量的影响。方法将78个确诊为 DN、且中医证型属于肝肾阴虚的患者纳入研究，采用数字表法随机分组，对照组40例，观察组38例，两组均行西药常规治疗，观察组加中药；观察两组24 h 尿蛋白计数、血糖（FBG、2 hPG）、血脂系列（TC、TG、LDL-C、HDL-C）、UAER、ACR、SCr、BUN 及生活质量 SF-36的变化情况；观察是否出现不良反应。结果两组血糖、血压、UAER、ACR、SCr、BUN、SF-36评分、尿蛋白计数较前改善，观察组治疗后6个月24 h 尿蛋白（1．02±0．42）g，明显低于对照组，差异有统计学意义（t ＝2．702，P ＜0．05）；观察组治疗后UAER、ACR、SCr、BUN 分别为（82．09±10．74）mg／24 h、（84．92±9．33）mg／g、（108．43±38．35）mmol／L、（6．17±2．65）mmol／L，均优于对照组，差异均有统计学意义（t ＝8．960，P ＜0．01；t ＝15．528，P ＜0．01；t ＝11.987，P ＜0．01；t ＝10．566，P ＜0．01）；无不良反应发生。结论应用中西结合治疗早期 DN 疗效确切，能改善肾功能，安全可靠，优于单独使用西药治疗。
Objective To investigate the effect of traditional Chinese medicine on the renal function and quality of life in patients with early diabetic nephropathy （DN）.Methods 78 diagnosed as DN and TCM syndrome type belonged to cases of yin deficiency of liver and kidney were included in the study,they were randomly divided into the control group（40 cases）and observation group （38 cases）.The two groups underwent conventional treatment of western medicine,the observation group received traditional Chinese medicine.The 24h urine protein counts,blood glucose （FBG,2hPG）,lipid column （TC,TG,LDL -C,HDL -C）,UAER,ACR,SCR,bun and quality of life of SF-36,adverse reaction were observed.Results The blood glucose,blood pressure,UAER,ACR,SCR,BUN,SF -36 score,urinary protein count of the two groups were improved than before treatment.6 months after treatment,the 24h urine protein of observation group was （1.02±0.42）g,which was significantly lower than the control group,the difference was statistically significant （t =2.702,P〈0.05）.After treatment,UAER,ACR,SCr,BUN of the observation group were （82.09 ±10.74）mg/24h,（84.92 ±9.33）mg/g,（108.43 ±38.35）mmol/L,（6.17 ±2.65）mmol/L, which were better than the control group,the differences were statistically significant （t =8.960,P〈0.01;t =15.528,P〈0.01;t =11.987,P〈0.01;t =10.566,P〈0.01）.No adverse reaction was observed.Conclusion The combination of Chinese and western medicine in the treatment of early DN has good efficacy and better than the use of western medicine alone,it can improve renal function and is safe and reliable.
出处
《中国基层医药》
CAS
2015年第23期3642-3645,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
药物疗法
联合
糖尿病肾病
生活质量
Drug therapy,combination
Diabetic nephropathy
Quality of life
