摘要
目的:探讨龙鳖胶囊对膝骨关节炎(KOA)大鼠体质量及脏器指数的影响。方法:建立KOA大鼠模型,于造模后开始给予低、中、高剂量龙鳖胶囊(0.3125,0.625,0.9375g/kg)灌胃,连续4周,观察龙鳖胶囊对KOA大鼠体质量及脏器指数的影响。结果:造模后,造模组体质量和胸腺指数低于对照组(P<0.05),而脾脏指数与对照组比较,差异无统计学意义。给药2周后,龙鳖中剂量组的体质量重于对照组(P<0.05),而龙鳖低、高剂量的体质量与对照组比较,差异均无统计学意义;各组之间的脾脏指数差异也不显著;龙鳖低、中、高剂量组的胸腺指数均高于同期造模组(P<0.05)。给药4周后,龙鳖低、中、高剂量的体质量均重于对照组(P<0.05),其中,龙鳖中剂量组又重于龙鳖低、高剂量组(P<0.05);龙鳖低、中、高剂量组的脾脏指数均高于同期对照组(P<0.05);各组组间的胸腺指数比较,差异无统计学意义。结论:龙鳖胶囊能增加KOA大鼠体质量及脾脏指数,使降低的胸腺指数恢复至正常水平,其治疗KOA的作用可能与增强大鼠免疫器官的功能相关。
Objective: To investigate the effect of Longbie Capsule on body weight and organ indexes of knee osteoarthritis(KOA) rats. Methods: KOA rat models were established, and then received gavage administration with Longbie Capsule in the dose of 0.3125, 0.625, 0.9375g/kg for 4 weeks. The body weight and the organ indexes of rats in each group were observed. Results: After modeling, the body weight and the thymus index of rats in model group were lower than that of control group(P<0.05), and the difference in spleen index between model and control groups were not significant. After treating for 2 weeks, the body weight of rats in middle dosage of Longbie Capsule group was higher than that of control group(P<0.05), and the difference in body weight and spleen index between low and high dosage of Longbie Capsule groups and control group were not significant. The thymus index of rats in middle and high dosage of Longbie Capsule group was higher than that of model group(P<0.05). After treating for 4 weeks, the body weight of rats in low, middle and high dosage of Longbie Capsule groups was higher than that of control group(P<0.05), and the body weight of rats in middle dosage of Longbie Capsule group was higher than that of low and high dosage of Longbie Capsule groups(P<0.05). The spleen index of rats in low, middle and high dosage groups was higher than that of model and control groups(P<0.05), and the difference in thymus index among the three groups was not significant. Conclusion: Longbie Capsule could increase the body weight and spleen index, and decrease the thymus index of KOA rats to the normal level. The curative effect on KOA might correlate with the function enhancement of immune organs of KOA rats.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第8期3234-3237,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81473698
No.81273781)
教育部高等学校博士点科研基金项目(No.20124425110004)
广东省科技计划项目(No.2011B031700027)
广东省财政厅项目(No.[2014]157号)
广东省中医院中医药科学技术研究专项资助(No.YK2013B2N19
No.YN2015MS15)~~
关键词
胶原蛋白酶
膝骨关节炎
体质量
脾脏指数
胸腺指数
龙鳖胶囊
机制
Collagenase
Knee osteoarthritis(KOA)
Body weight
Spleen index
Thymus index
Longbie Capsule
Mechanism
