不同剂量地佐辛对乳腺癌根治术患者术后细胞免疫功能和细胞因子的影响被引量：13

在线阅读下载PDF

导出

摘要目的:观察不同剂量地佐辛对乳腺癌根治术患者术后T淋巴细胞亚群、NK细胞和IL-2和IL-10的浓度的影响。方法:40例乳腺癌根治术患者随机分为D1组和D2组,每组20例。麻醉诱导静注地佐辛0.2 mg/kg,术后患者静脉自控镇痛(PCIA)用地佐辛0.5 mg/kg(D1组)或0.8 mg/kg(D2组)。记录术后VAS评分,于麻醉前(T0)、术毕(T1)、术后1(T2)、3(T3)、7 d(T4)抽血检测T淋巴细胞亚群(CD3+、CD4+、CD8+水平以及CD4+/CD8+比值)和NK细胞水平以及血清IL-2和IL-10浓度。结果:D1组术后4 h时VAS高于D2组(P<0.05);D1组T1、T2时点CD3+、CD4+水平以及CD4+/CD8+比值和NK细胞水平高于D2组(P<0.05);D1组T2时血清IL-2浓度高于D2组(P<0.05)。结论:地佐辛对于乳腺癌根治术患者术后细胞免疫功能的抑制作用和细胞因子的调节作用呈剂量依赖性。

作者凌晨邹林邓爱红周少雄胡旭东陈岸洪钦政黄浩铭孙来保

机构地区佛山市第二人民医院麻醉科佛山市第二人民医院检验科佛山市第二人民医院胸外科中山大学附属第一医院麻醉科

出处《实用医学杂志》 CAS 北大核心 2015年第23期3944-3946,共3页 The Journal of Practical Medicine

基金广东省科技计划项目(编号:2012A030400042)

关键词乳腺癌根治术地佐辛剂量 T淋巴细胞亚群白介素-2 白介素-10

分类号 R614 [医药卫生—麻醉学] R737.9 [医药卫生—肿瘤]

引文网络
相关文献

参考文献10

1Kajitani K, Tanaka Y, Arihiro K, et al. Mechanistic analysis of the antitumor efficacy of human natural killer cells against breast cancer cells [ J ]. Breast Cancer Res Treat, 2012,134 ( 1 ) : 139- 155.
2李琼珍,朱涛.术后镇痛对免疫功能的影响[J].实用医学杂志,2010,26(12):2251-2252. 被引量：26
3Sacerdote P1, Franchi S, Panerai AE. Non-analgesic effects of opioids : mechanisms and potential clinical relevance of opioid- induced immunodepression [J]. Curt Pharm Des, 2012,18 (37) : 6034-6042.
4Yardeni IZ, Beilin B, Mayburd, et al. Relationship between de- zocine dosage and immune function in the mice [J]. L Opioid Manag, 2008,4( 1 ) : 27-33.
5凌晨,胡旭东,张利国,杜顺颜,吴亚彬,陈岸,洪钦政,黄浩铭,孙来保.乳腺癌根治术患者术后不同镇痛方式对细胞免疫功能及炎症介质的影响[J].广东医学,2015,36(4):551-553. 被引量：46
6靳红绪,李凤丹,张同军,孙学飞,王忠义.地佐辛复合舒芬太尼术后自控静脉镇痛对肿瘤患者T淋巴细胞亚群和NK细胞水平的影响[J].实用医学杂志,2013,29(6):982-984. 被引量：31
7Boland JW, Foulds GA, Ahmedzai SH, et al. A preli minary e- valuation of the effects of opioids on innate and adaptive human in vitro immune function [J]. BMJ Support Palliat Care, 2014,4 (4) : 357-367.
8Beilin B1, Shavit Y, Hart J, et al. Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cyto- toxicity in the perioperative period [J]. Anesth Analg, 1996,82 (3) : 492-497.
9Renyu Liu, Xi-Ping Huang, Alexei Yeliseev, et al. Novel molecular targets of dezocine and their clinical implications [J]. Anesthesiology, 2014,120(3) :714-723.
10Finley MJ, Happel CM, Ka minsky DE, et al. Opioid and noci- ceptin receptors regulate cytokine and cytokine receptor expres- sion [J]. Cell Immunol, 2008,252(1-2) : 146-154.

二级参考文献17

1胡冬华,李雅兰,蔡明雪,张惠,项明方,帅兵,聂偲.硬膜外布托啡诺用于老年患者髋关节置换术后镇痛[J].南方医科大学学报,2009,29(7):1435-1437. 被引量：10
2易斌,陶国才,阮志华,张铭.乳腺癌根治术患者术后不同镇痛方式对T细胞亚群和自然杀伤细胞活性的影响[J].中华麻醉学杂志,2005,25(3):213-214. 被引量：26
3Bonz A W, Lengentfelder B, Jaclbs M, et al. Cytokine response after percutaneous coronary Intervention in stable angina: effect of selective gly coprotein Ⅱ b/Ⅲa receptor antagonism [J]. Am Heart J, 2003,145(4) :693-699.
4Snyder G L, Greenherg S. Etfect of anaesthetic Jechnlque and other perioperative factors on cancer recurrence [J]. Br J Anaesth, 2010, 105(2) : 106-115.
5Vallejo R, Hord E D, Barna S A, et al. Perioperative immunosuppression in cancer patients [J]. J Environ Pathol Toxicol Oncol, 2003,22(2) : 139-146.
6Milasiene V, Stratilatovas E, Norkiene V, et al. The importance of T-lymphocyte subsets on overall survival of colorectal and gastric cancer patients [ J ]. Medicine (Kaunas), 2007,43 (7) : 548-554.
7Angele M K, FaisL E. Clinical review: immunndepression in the surgical patient and increased susceptibility to infection [ J ]. Crit Care, 2002,6 (4) : 298-305.
8Kim R, Emi M, Tanabe K. Cancer immunoediling from immune surveillance to immune escape [J]. Immunology, 2007,121(1) : 1-14.
9Zollner C, Schafer M. Opioids in anesthesia [J]. Anaesthesist, 2008,57 (7) : 729-742.
10Liao S L, Chen W Y, Raung S L, et al. Neuropr olection of naloxone against ischemic injury in rats: role of mu receptor antagonism [J]. Neurosci Lett, 2005,345(5) : 169-172.