摘要
目的探讨调强放疗联合化疗治疗局部晚期鼻咽癌的临床疗效和安全性。方法入组初治局部晚期鼻咽癌患者120例,随机均分为2组,每组60例,分别接受调强放疗联合化疗(观察组)和单纯调强放疗(对照组),比较观察2组的治疗情况和安全性。结果观察组累计区域进展率、远处转移率、死亡率均低于对照组,差异有统计学意义(P<0.05)。观察组急性放射损伤和慢性放射损伤发生方面,优于对照组,但差异无统计学意义(P>0.05)。观察组放疗毒副反应方面仅白细胞减少发生率高于对照组,差异有统计学意义(P<0.05)。结论与单纯调强放疗相比,调强放疗联合化疗在控制疾病的局部进展、淋巴结转移和死亡方面具有优势,安全性两者相当,是治疗局部晚期鼻咽癌的值得推荐的方法。
Objective To investigate the efficacy and safety of intensity-modulated radiotherapy combined with chemotherapy in the treatment of local advanced nasopharyngeal carcinoma. Methods The 120 patients with local ad- vanced nasopharyngeal carcinoma were divided into two groups, and received intensity-modulated radiotherapy combined with chemotherapy （ 60 patients of the observation group） and chemotherapy alone （ 60 patients of the control group）, respectively. The treatment and safety were compared between the two groups. Results The regional develop- ment rate, the distant metastasis rate and the mortality rate in the observation group were significantly lower than those in the control group （ P 〈 0.05 ）. The acute and chronic radiation injury of the observation group was superior to the control group, but the difference was not statistically significant （ P 〉 0.05 ）. The incidence of leukopenia in the obser- vation group was higher than that in the control group （ P 〈 0.05 ）. Conclusion For local advanced nasopharyngeal carcinoma,intensity-modulated radiation therapy combined with chemotherapy is superior to pure intensity-modulated chemotherapy in the regional development,distant metastasis and the mortality; the safety is similar,intensity-modulated radiation therapy combined with chemotherapy is a worth clinical recommendation regimen.
出处
《肿瘤基础与临床》
2015年第6期487-490,共4页
journal of basic and clinical oncology
关键词
鼻咽癌
调强放疗
化疗
nasopharyngeal carcinoma
intensity-modulated radiotherapy
chemotherapy
