摘要
目的 观察两种稀释浓度A型肉毒毒素（BTX-A）治疗动力性额横纹的疗效及不良反应.方法 将符合纳入标准的103例患者按随机数字表法分为高浓度组53例和低浓度组50例,分别采用50 U/ml和25 U/ml浓度BTX-A局部注射额部,观察两组的BTX-A用量、治疗效果、疗效持续时间及不良反应.结果 高浓度组BTX-A用量为（45.53±2.05）U,低浓度组BTX-A用量为（25.71±1.74）U,差异有统计学意义（P＜0.05）.高浓度组和低浓度组术后评分差、起效时间和维持时间,差异均无统计学意义（P＞0.05）.高浓度组术后发生额部沉重感30例（88.24％）,低高浓度组术后发生额部沉重感2例（5.71％）,差异有统计学意义（P＜0.01）.两组均未做特殊处理,2周时间内症状自行消失.两组均未出现中毒、药物过敏反应等严重并发症.结论 两种稀释浓度BTX-A局部注射治疗动力性额横纹疗效肯定,两组持续时间相仿.为减少额部沉重感,推荐使用25 U/ml稀释浓度方案.
Objective To assess the efficacy and adverse reactions of two cconcentrations of diluted botulinum toxin A for dynamic frontotransverse wrinkles.Methods Totally 103 cases met the inclusion criteria were assigned into two groups by a random number table：high concentration group （50 U/ml,53 cases） and low concentration group （25 U/ml,50 cases）.The two groups were given the local injection with 50 U/ml and 25 U/ml concentration of botulinum toxin type A,respectively.Dosage of BTX-A,the treatment effect,the duration of the effect and the incidence of adverse reactions were analyzed.Results The high concentration group were given the BTX-A （45.53±2.05） U,the low concentration group were given the BTX-A （25.71 ± 1.74） U,and the difference were statistically significant （P〈0.05）.The differences of post-operative evaluation,time of onset and duration between the two groups were not statistically significant （P〉0.05）.In the high concentration group,30 cases （88.24%） had forehead heaviness sensation,and 2 cases （5.71%） in the low concentration group,the difference were statistically significant （P〈0.01）.Neither of the groups was given any specific treatment,the symptoms were disappeared in two weeks.In either group there was no serious complications such as intoxication,allergy,etc.Conclusions The efficacy of local injection with two concentrations of diluted botulinum toxin A in the treatment of dynamic frontotransverse wrinkles is positive,the duration of treatment effect between the two groups is similar,and therefore the 25 U/ml concentration is recommended to reduce the forehead heaviness sensation.
出处
《中华医学美学美容杂志》
2015年第6期354-356,共3页
Chinese Journal of Medical Aesthetics and Cosmetology
