摘要
该文基于个性化Willis环的颈动脉-眼动脉瘤模型,通过计算机数值分析和体外实验考察了完整Willis环结构内眼动脉瘤对血流调节的影响。计算结果显示,当右侧颈动脉与眼动脉分叉处形成动脉瘤以后,同侧的眼动脉以及中脑动脉的流量增加。同时,右侧后交通动脉的流动发生转向,由之前的颈动脉至后脑动脉变成了由后脑动脉至颈动脉。该结果与基于个性化模型的实验结果完全一致。这些结果表明,动脉瘤的存在会明显改变Willis环的血流特性,使脑血流通过交通动脉的调节实现重新分配。研究也进一步验证了交通动脉在Willis环血流调节中的重要作用。
In this study, the effect of the aneurysm on cerebral blood flow regulation is investigated by using a computational and in-vitro patient-specific model for the circle of Willis with an ophthalmic artery aneurysm. The computational results show that when an aneurysm appears at the bifurcation of internal carotid artery and the ophthalmic artery, the flow rate increases in the ophthalmic artery and the middle cerebral artery for the same side. In the meantime, the flow direction in the posterior communicating artery of the same side is reversed and the flow direction is from the right posterior artery to the right carotid artery. The same phenomenon is also found in the in-vitro experiment. These results imply that the characteristics of the flow in the entire circle of Willis are considerably changed with the formation of the aneurysm. Its existence leads to the redistribution of blood flow via communicating arteries. The critical role of the communicating arteries for blood regulation is further confirmed as well.
出处
《水动力学研究与进展（A辑）》
CSCD
北大核心
2015年第6期707-715,共9页
Chinese Journal of Hydrodynamics
基金
国家自然科学基金(51576033)
北京临床生物力学应用基础研究重点实验室开放课题项目(2015LCLX03)~~
关键词
WILLIS环
血流调节
动脉瘤
计算模型
个性化体外模型
circle of Willis
blood flow regulation
aneurysm
computational model
patient-specific in-vitro model
