摘要
在我国,胃肠道肿瘤发病率和病死率居恶性肿瘤前列,早期诊断是提高存活率的关键.近年来,内镜下分子成像在肿瘤诊断方面以其独特的优势受到了越来越多的关注.随着分子生物学的快速发展,肿瘤发生发展的机制逐渐探明,研究者利用荧光标志分子探针,靶向结合于消化系肿瘤中的分子靶点,使得在内镜下实时对消化系肿瘤进行分子诊断成为可能,同时对肿瘤的靶向治疗也可产生一定影响.本文就消化系肿瘤内镜下分子成像的研究进展作一综述.
In China,the incidence and mortality of gastrointestinal cancers are high,and early diagnosis is the key to improving the survival rate.In recent years,endoscopic molecular imaging in tumor diagnosis with its unique advantages has attracted more and more attention.With the rapid development of molecular biology,the mechanism of tumor occurrence and development has been gradually elucidated.The advent of fluorescent labeled molecular probes and targeted binding to molecular targets of gastrointestinal tumors makes it possible achieve real-time endoscopic molecular diagnosis of digestive tract tumors,which has a significant impact on tumor targeted therapy.In this paper,we review the progress in endoscopic molecular imaging of digestive tract tumors.
出处
《世界华人消化杂志》
CAS
2015年第33期5333-5341,共9页
World Chinese Journal of Digestology
关键词
消化系肿瘤
分子影像
消化内镜
Digestive tract tumors
Molecular imaging
Digestive endoscopy
