摘要
目的探讨糖皮质激素治疗急性重症胰腺炎的临床疗效和价值。方法将122例急性重症胰腺炎患者随机分为对照组和治疗组,各61例。两组均给予禁食、胃肠减压、抗炎、抑酸、使用生长抑素及监护等常规治疗,治疗组在此基础上早期给予地塞米松磷酸钠注射液20 mg,每天2次,3~5 d停药。结果治疗组患者在腹痛腹胀缓解时间、发热时间、血淀粉酶水平、多器官功能障碍综合征（MODS）、肾功能衰竭、休克发生率,死亡率,住院时间以及临床费用方面明显优于对照组（P〈0.05）。结论在急性重症胰腺炎治疗中,早期、足量的使用地塞米松能明显减少MODS等严重并发症,明显减轻病情,缩短疗程,降低死亡率,减少临床费用。
Objective To investigate the efficacy of glucocorticoid in treating acute pancreatitis. Methods 122 cases of acute pancreatitis patients were randomly divided into the control group and treatment group,both of which were treated with conventional therapy including fasting, gastrointestinal decompression, anti- inflammatory, inhibition of gastric acid secretion and somatostatin. Besides, the treatment group was treated with dexamethasone（ 20 mg iv,bid for 3- 5 d）. Results The occurrence rate of shock,mortality,acute respiratory distress syndrome（ ARDS） and acute renal failure（ ARF） in treatment group was significantly lower than control group. Moreover, the relief of abdominal pain, abdominal distension and blood amylase were also more effective in treatment group patients. As a result, the treatment group was better than the control group in the fields of hospitalization time and fees（P 〈 0. 05）. Conclusion Dexamethasone treatment could not only decrease the occurrence rate of severe complications such as ARDS and ARF,but also shorten the hospitalization time of acute pancreatitis patients.
出处
《中国药业》
CAS
2015年第23期60-61,共2页
China Pharmaceuticals
