摘要
目的考察文拉法辛与普瑞巴林改善纤维肌痛综合征患者疼痛和心理障碍的临床效果。方法将120例纤维肌痛综合征患者随机分为3组,每组40例。A组给予普瑞巴林治疗、B组给予文拉法辛治疗、C组给予普瑞巴林联合文拉法辛治疗。比较三组患者的纤维肌痛影响问卷(FIQ)得分、心理症状自评量表(SCL-90)得分、视觉疼痛模拟量表(VAS)得分及不良反应发生率。结果治疗后C组患者FIQ得分显著低于A组、B组(P<0.01),治疗后A组和C组患者SCL-90多项指标得分显著低于B组(P<0.05),治疗后C组患者VAS得分显著低于A组、B组(P<0.01),三组间不良反应发生率比较差异无统计学意义(P>0.05)。结论文拉法辛联合普瑞巴林治疗纤维肌痛综合征临床效果更好,患者心理障碍更少、疼痛更轻,具有临床应用价值。
Objective To study the clinical effects of venlafaxine combined with pregabalin on the psychologi- cal disorders and pain in patients with fibromyalgia syndrome. Methods A total of 120 patients with fibromyalgia syn- drome were randomly divided into three groups. Patients in group A （n = 40 ） were treated by venlafaxine, patients in group B （ n = 40 ） were treated by pregabalin, and patients in group C （ n = 40 ） were treated by venlafaxine combined with pregabalin. The fibromyalgia impact questionnaire （ FIQ ） , symptom checklist 90 （ SCL-90 ） , the Visual analog scale（VAS） and the adverse reaction rates were compared among the three groups. Results The FIQ score in group C was significantly less than those of group A and group B （ P 〈 0. 01 ）. Several indexes of SCL-90 in group A and group C were significantly less than that of group B after treatment （ P 〈 0. 05 ）. The VAS score in group C was significantly less than those of group A and group B （ P 〈 0. 01 ）. There was no significant difference in adverse reaction rate among the three groups （ P 〉 0. 05 ）. Conclusion Venlafaxine combined with pregabalin has great clinical effects on fibromy- algia syndrome,it can improve the psychological disorders and pain, and it is worthy of clinical application.
出处
《实用药物与临床》
CAS
2015年第12期1516-1519,共4页
Practical Pharmacy and Clinical Remedies
