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CD44与乳腺癌的相关研究进展 被引量：3

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摘要 细胞粘附因子CD44是一种细胞表面跨膜糖蛋白,它能将信号从细胞表面受体传导至细胞核,介导相关因子的转录活化,从而影响细胞的增殖、凋亡与癌变等多种生物学反应;CD44+/CD24-/LOW蛋白是指表达CD4 4基因,不表达或低表达CD24基因的细胞表面糖蛋白,它是乳腺癌干细胞表面标志物。CD44、CD44+/CD24-/LOW与乳腺癌复发转移相关,下调CD44或CD44+/CD24-/LOW可以有效降低乳腺癌细胞增殖侵润转移能力。
作者 申辉 罗赤苗
机构地区 南华大学附属邵阳市中心医院普外科
出处 《内江科技》 2015年第12期115-117,共3页
关键词 乳腺癌细胞 转录活化 癌细胞增殖 生物学反应 三阴乳腺癌 相关因子 曲妥珠单抗 组成型外显子 低表达 转移能力
分类号 R737.9 [医药卫生—肿瘤]
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参考文献22

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  • 4Jino Park, Michaela Schlederer, Martin Schreiber,et al.AFlq is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis[J].Oncotarget, 2015,6(24):20697-20710.
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二级参考文献80

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共引文献29

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内江科技
2015年 第12期

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