摘要
目的观察白芍总苷治疗寻常型银屑病的临床疗效及对复发的影响。方法将符合入选标准的96例寻常型银屑病患者随机分成2组,对照组予窄谱中波紫外线(UVB)照射及外用保湿剂治疗,治疗组加用白芍总苷胶囊口服,治疗3个月、6个月进行银屑病皮损面积和严重程度(PASI)评分,随访治疗后6,12,18及24个月内皮损复发情况。结果治疗3个月时治疗组PASI较对照组有明显改善(P<0.05);治疗6个月时治疗组PASI较对照组有显著改善(P<0.01),PASI较治疗3个月时有明显改善(P<0.05)。治疗组在治疗3,6个月时临床有效率较对照组差异有统计学意义(分别为P<0.05,P<0.01)。治疗组在治疗后6个月时复发率与对照组差异无统计学意义(P>0.05);在治疗后12,18个月时复发率较对照组差异有统计学意义(P<0.05);治疗后24个月时复发率治疗组较对照组,差异有统计学意义(P<0.01)。结论治疗组较对照组对寻常型银屑病患者皮损面积及严重程度有着明显的改善,随疗程的延长改善更显著;随着随访时间的延长,治疗组复发率更低。
Objective To evaluate the clinical efficacy and impact of total glucosides of paeony（TGP） for the treatment and recurrence of psoriasis. Methods All of 96 patients with psoriasis vulgaris judged by the inclusion criteria were randomly divided into two groups, the control group was treated with narrow-band ultraviolet B（NB-UVB） irradiation and topical moisturizer, and the treatment group was added with TGP oral capsules for three months or six months. Psoriasis area and severity index（PASI） score was conducted and followed the recurrence of skin lesion within six, 12, 18 and 24 months after treatment. Results PASI in the treatment group was significantly improved than that in the control group after three months＇ treatment（P〈0.05）; and PASI in the treatment group was significantly improved than that in the control group after six months＇ treatment（P〈0.01） and after three months＇ treatment（P〈0.05）. The difference was statistically meaningful in clinical efficiency between the treatment group and the control group after three months＇ treatment（P〈0.05） and after six months＇ treatment（P〈0.01）. The six months treatment group on recurrence rate had no statistical difference compared with the control group（P〉0.05）; the recurrence rates of the 12 months and 18 months treatment group were lower than those of the control group, which was statistically meaningful（P〈0.05）. The difference was statistically meaningful in recurrence rate between the 24 months treatment group and the control group（P〈0.01）. Conclusion The treatment group compared with the control group in psoriasis area and severity has significantly improved, with the course prolonged gradually has a more significant improvement. With the followed time extended, the recurrence rate in the treatment group is lower.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2015年第6期371-373,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
中华医学会基金项目
关键词
白芍总苷
寻常型银屑病
临床疗效
复发率
Total glucosides of paeony
Psoriasis
Clinical efficacy
Recurrence rate
