摘要
目的比较局部晚期喉癌和下咽癌Rapid Arc(RA)容积旋转调强放疗与螺旋断层放疗(HT)剂量学差异,探讨2种调强技术特点及剂量学优势。方法选取10例喉癌(4例)和下咽癌(6例)术后患者,分别设计RA、HT两组治疗计划,比较靶区及危及器官剂量分布、剂量体积直方图(DVH)等指标情况,并对机器跳数(MU)与出束时间予以评估。结果两者均实现了95%以上靶体积的剂量覆盖,并体现出类似的剂量均匀性。RA组腮腺、口腔V10较HT组分别降低了9.6%、13.6%(P=0.03/0.00),而HT组V40却降低了13.4%、13.7%(P=0.00/0.21)。在减少正常组织(NT)受量上RA更具优势,而HT实现了对脊髓更好的避让。RA/HT两组计划的平均机器跳数和出束时间分别为820 MU/5367 MU、377 s/150 s。结论两种旋转调强技术均能较好地实现喉癌和下咽癌照射,且RA在减少低剂量照射及计划实施效率上更具优势。
Objective To compare the dosimetric characteristics of helical tomotherapy（ HT） and Rapid Arc（ RA）therapy for laryngeal and hypopharyngeal carcinoma. Methods 10 patients with post-operative laryngeal or hypopharyngeal carcinoma were enrolled in this study. RA plans and HT plans were created for each patient and according to dose-volume histogram（ DVH） analysis in terms of PTV homogeneity and conformity indices（ HI and CI） as well as OARs dose and volume parameters were compared. Additionally,the cumulative monitor unit（ MUs） and treatment delivery times of the different technologies were analyzed. Results The 2 techniques could well achieve the target coverage（ 95%） and showed a similar dose uniformity. RA showed better in the low dose distribution of the organs such as parotids and oral,but the HT plans have a visible advantage over the RA plans in the high dose,the V40 of parotids and oral were reduced by 13. 4%,13. 7%（ P = 0. 00 /0. 21）. The MU and treatment delivery time of RA and HT were 820 MU /5 367 MU,377 s /150 s. Conclusion The 2 kinds of treatment plans can provide good dose distribution. And RA seems to be obviously better in low dose distribution and the delivery efficiency.
出处
《实用癌症杂志》
2016年第1期120-123,共4页
The Practical Journal of Cancer
关键词
喉癌
下咽癌
快速容积旋转调强
螺旋断层放射治疗
剂量学
Laryngeal carcinoma
Hypopharyngeal carcinoma
Tomotherapy
Intensity-modulated Arc Therapy
Dosimetry
