摘要
目的探讨急性心肌梗死（AMI）患者血浆脑钠肽（BNP）、心钠素（ANP）、肌酸激酶同工酶（CKMB）水平变化特点及临床意义。方法选取2013年1月～2014年12月来我院治疗的110例AMI患者为研究对象（AMI组），另外选取我院同期110例体检健康者为对照组，检测两组血浆BNP、CKMB、ANP水平，分析其治疗前后水平变化特点。结果治疗前AMI组的BNP、ANP、CKMB水平均高于对照组（P〈0．01）；治疗后，AMI组BNP、ANP、CKMB水平较治疗前显著降低，但仍高于对照组（均P〈0．01）。治疗前，AMI患者前壁梗死组BNP、CKMB、ANP水平明显高于下壁梗死组（P〈0．05）；治疗结束后30d内，发生心血管事件（再发心肌梗死、心力衰竭）组BNP、ANP、CKMB水平均显著高于未发生组（P〈0．05）。结论血浆BNP、CKMB、ANP水平检测对于AMI患者诊断、病情监测具有重要临床意义。
Objective To explore the characteristics of plasma brain natriuretic peptide （BNP）, atrial natriuretic peptide （ANP）, and creatine kinase （CKMB） level changes in patients with acute myocardial infarction （AMI） and the clinical significance. Methods 110 cases of AMI patients receiving treatment in the hospital between January 2013 and December 2014 were selected as AMI group, and other 110 persons taking health examination at the same period were chosen as control group. The plasma BNP, CKMB, and ANP levels in both groups were detected in order to analyze the changes before and after the treatment. Results Before the treatment, the BNP, ANP, and CKMB levels in AMI group were all higher than those in the control group （P 〈 0.01）. After the treatment, the levels of the three indexes above in AMI group significantly decreased but still higher than those in the control group （both P 〈 0.01）. Before the treatment, the BNP, CKMB, and ANP levels of the patients with anterior myocardial infarction were significantly higher than those of the patients with inferior wall myocardial infarction （P 〈 0.05）. Within 30 days after the treatment, the levels of the three indexes in the group with the occurrence of cardiovascular events （recurrent myocardial infarction and heart failure） were all higher than those in the group without the occurrence （P 〈 0.05）. Conclusion The detection of plasma BNP, CKMB, and ANP levels has important significance for the diagnosis and disease surveillance of AMI patients.
出处
《西南国防医药》
CAS
2016年第1期17-20,共4页
Medical Journal of National Defending Forces in Southwest China
