摘要
目的 建立祛斑口服液的质量标准。方法 采用薄层色谱法（TLC）对处方中的党参、黄芪、赤芍、白芍、白术、当归进行定性鉴别;采用反相高效液相色谱法（RP-HPLC）对处方中赤芍和白芍中的芍药苷进行含量测定。结果 定性鉴别方法分离良好、斑点清晰、专属性强。芍药苷检测浓度在18.20~2 330.00μg/ml范围内与峰面积积分值呈良好的线性关系（r=0.999 9）,平均回收率为99.72%,RSD为1.25%。结论 本方法可对祛斑口服液的主要药味进行准确的定性和定量测定,有效地控制祛斑口服液的质量。
Objective To establish the quality standard for Quban oral liquid. Method Thin layer chromatography （TLC）was used for quality identification of Codonopsis pilosula, Astragalus membranaceus, Paeonia veitchii, Paeonia lacti- flora, Atractylodes rnacrocephala and Angelica sinensis. The paeoniflorin was determined by RP-HPLC. Result Clear spots were obtained with good separation in TLC identification which was highly specific. The paeoniflorin area and content showed a good linear relationship at the range of 18. 20-2 330. 00 μg/ml （r= 0. 999 9）. The average recovery was 99. 72% （RSD= 1.25%）. Conclusion This method is simple, rapid, accurate, and which can be used for the quality control of Quban oral liquid.
出处
《药学实践杂志》
CAS
2016年第1期66-71,共6页
Journal of Pharmaceutical Practice
基金
军队医疗机构制剂标准提高计划(14ZJZ02-4)
