摘要
目的探讨糖皮质激素联合用药方案对特发性肺纤维化（IPF）的治疗效果。方法将116例IPF患者分为试验组和对照组,各58例。对照组患者采用泼尼松＋环磷酰胺的方法,试验组患者采用泼尼松＋乙酰半胱氨酸泡腾片,疗程均为6个月。结果试验组的改善率为86.21%,明显高于对照组的58.62%（χ~2=60.83,P〈0.05）;试验组在症状改善率、活动量增加率、HRCT异常影像改善率等显著高于对照组（P〈0.05）;肺功能方面,试验组除了肺活量以外的其他指标改善率均显著高于对照组（P〈0.05）。结论糖皮质激素联合N-乙酰半胱氨酸治疗IPF的疗效优于联合环磷酰胺。
Objective To investigate the efficacy of glucocorticoid combined with acetylcysteine in treating idiopathic pulmonary fibrosis（ IPF）. Methods 116 patients with IPF were divided into experimental and control groups,58 cases in each group. The control group was treated with prednisone and cyclophosphamide, the experimental group were treated with prednisone ＋ acetylcysteine effervescent tablets. The treatment course for both groups was 6 months. Results The improvement rate of the experimental group was 86. 21%,which was significantly higher than 58. 62% of the control group（ χ~2= 60. 83,P〈0. 05）; the experimental group was significantly higher than the control group in symptom improvement rate,activity rate of increase,HRCT abnormalities image improvement rate（ P〈0. 05）;in the area of lung function, the experimental group was significantly higher in the improvement rate of other indicators in addition to vital capacity than the control group（ P〈0. 05）. Conclusion Glucocorticoid combined with acetylcysteine in treating IPF has superior efficacy to cyclophosphamide.
出处
《中国药业》
CAS
2016年第1期99-101,共3页
China Pharmaceuticals
