摘要
目的探讨幽门螺杆菌（Helicobacter pylori，H.pylori）感染与反流性食管炎（Reflux esophagitis，RE）二者之间的关系。方法选取2010年1—12月在我院消化内科门诊就诊，经内镜检查确诊为反流性食管炎的364例患者作为研究对象。364例患者的食管炎程度按洛杉矶标准进行分级，记为相应的A（156例）、B（196例）、C（7例）、D（5例）4组。内镜下常规取胃窦黏膜组织2—3块送病理检查，标本分别行HE染色明确胃炎类型、炎症活动度及快速尿素酶实验、改良Giemsa染色明确H.pylori感染情况等。结果反流性食管炎患者中以男性多见，平均发病年龄早于女性平均发病年龄[（52．4±11．6）岁vs（56．6±12．4）岁，P=0．002]；门诊反流性食管炎患者的总体H．pylori感染率为90．9％，以轻度H．pylofi感染为主，四组的H．pylori感染率及感染程度的比较差别无统计学意义（P值分别为0．419，0．332）；反流性食管炎患者以慢性浅表性胃炎、中度活动性炎症为主，四组比较差别无统计学意义（P值分别为0．146，0．496）；H．pylori阳性、阴性患者的食管炎程度比较差别无统计学意义（P〉0．05）；不同程度H．pylori感染情况下，患者的食管炎程度比较差别无统计学意义。结论四组反流性食管炎患者的H．pylori感染率及感染程度的比较无差别，H．pylori阳性患者与阴性患者的食管炎程度比较无差别，不同程度H．pylori感染情况下，患者的食管炎程度比较无明显差别。提示H.pylori感染与反流性食管炎程度无关。
Objective To explore the relationship between helicobacter pylori infection and reflux esophagitis. Methods 364 patients with reflux esophagitis were enrolled in our hospital from Jan to Dec in 2010. The severity grade of reflux esophagitis was according to Los Angles standard. All the patients received biopsies from gastric antrum, then received patholog- ic examinations. Results Reflux esophagitis in men was more common, with an average age of onset earlier than the female （52.4± 11.6 years vs 56. 6 ± 12.4 years, P =0. 002） ; Reflux esophagitis in patients with H. pylori infection rate was 90. 9% overall, mainly with mild infection, four groups of H. pylori infection rate and extent of infection was no significant difference （ P values were 0. 419, 0. 702） ; reflux esophagitis in patients with chronic superficial gastritis （ CSG）, moderate active inflammation based was more common, there was no statistically significant difference in four group （ P values were 0. 146, 0. 496 ）. There was no significant difference between H. pylori positive patients and H. pylori negative patients in esophageal mucosal damage （ P 〉 0. 05 ） . There was no significant difference in reflux esophagitis with varying degrees of H. pylori infection on the degree of esophagitis. Conclusion Four groups of H. pylori infection rate and extent of infection was no significant difference; there was also no significant difference between H. pylori positive patients and H. pylori negative patients in esophageal mucosal damage. There was no significant difference in RE with varying degrees of H. pylori infection on the degree of esophagitis. Our research showed H. pylori infection had no relationship with degree of RE.
出处
《广州医药》
2016年第1期46-48,共3页
Guangzhou Medical Journal
