摘要
目的探讨拉莫三嗪添加-替换治疗丙戊酸治疗无效的癫痫患者的临床疗效。方法选取2014年1月~2014年12月我院接受治疗的丙戊酸治疗无效的癫痫患者30例,对患者加以拉莫三嗪进行治疗,对患者的治疗效果及不良反应进行观察比较。结果 30例患者中,完成联合用药患者26例,剩余4例因不良反应不耐受而退出治疗。该26例患者中,完全控制者16例、有效者8例,其治疗总有效率为92.3%。后转化为拉莫三嗪单药治疗患者15例,且其中完全控制者6例、有效者5例,其治疗总有效率为73.3%。结论拉莫三嗪添加丙戊酸治疗丙戊酸无效的癫痫患者效果较好。
Objective To investigate clinical efficacy of lamotrigine add- replacement therapy for ineffective of valproate therapy in patients with epilepsy. Methods 30 cases of epileptic patients were treated in our hospital for valproate therapy from January 2014 to December 2014, they were treated with lamotrigine treatment, patient outcomes and adverse reactions were observed. Results In the 30 patients, 26 cases received combination therapy, and the remaining four cases had adverse reactions due to intolerance withdraw treatment. In the 26 patients, complete control in 16 cases, effective in 8 cases, the total effective rate was 92.3%. After conversion to lamotrigine monotherapy in 15 patients, and in which full control in 6 patients, effective in 5 cases, the total effective rate was 73.3%. Conclusion Lamotrigine combined with valproate in treatment of valproic acid ineffective patients with epilepsy has better effect.
出处
《中国继续医学教育》
2016年第3期175-176,共2页
China Continuing Medical Education
关键词
拉莫三嗪
丙戊酸
癫痫
疗效
Lamotrigine
Valproic acid
Epilepsy
Efficacy
