摘要
【目的】通过经颅多普勒超声(TCD)观察补阳还五汤对急性脑梗死患者侧支循环的影响。【方法】将符合纳入标准的80例急性脑梗死患者随机分为治疗组及对照组各40例,2组中途各脱落2例,最终各有38例纳入研究。对照组采用西医标准化治疗方案治疗,治疗组在对照组西医标准化治疗方案治疗基础上加服补阳还五汤,2组疗程均为7 d,于治疗3 d及治疗7 d后采用经颅多普勒超声观察2组责任血管血流速度及侧支循环代偿的改善情况,并于治疗7 d后行神经功能缺损评分(NIHSS)。【结果】(1)治疗组治疗3 d后出现侧支循环改善12例(占31.58%),治疗7 d后增加至16例(占42.11%);对照组治疗3 d与治疗7 d后出现侧支循环代偿改善分别为3例(占7.89%)和4例(占10.53%);治疗组在改善侧支循环代偿方面作用优于对照组(均P<0.01)。(2)治疗组治疗3 d后出现责任血管的平均血流速度(Vm)增快者9例,治疗7 d后增加至11例;对照组治疗3 d后与治疗7 d后出现责任血管的Vm增快者各只有1例;治疗组在改善责任血管的血流速度方面作用优于对照组(P<0.05)。(3)治疗7 d后,2组NIHSS评分均显著降低(P<0.05或P<0.01),且治疗组在改善NIHSS评分方面作用优于对照组(P<0.01)。(4)治疗组与对照组在治疗过程中均无不良事件发生。【结论】补阳还五汤能够持续促进责任血管血流速度的改善及促进侧支代偿血管的建立,挽救缺血半暗带,更好地促进患者的神经功能缺损的恢复。
Objective To observe the effects of Buyang Huanwu Decoction（BHD）on collateral circulation of patients with acute cerebral infarction（ACI）through transcranial Doppler sonography（TCD）. Methods The randomized controlled trial methods were applied, and 80 ACI patients were randomly divided into treatment group and control group,40 cases in each group. Two cases from each group were dropped out,and the left 38 cases of each group were included into the analysis. The control group was treated with the standardized western medicine regimen,and the treatment group was given BHD orally on the basis of treatment for the control group.The treatment for the two groups covered 7 days. On treatment day 3 and 7,TCD was adopted to investigate the blood flow velocity of the responsible vessels and the improvement of collateral circulation compensation. On treatment day 7, the scores of National Institute of Health Stroke Scale（NIHSS）in the two groups were compared.Results（1） On treatment day 3, collateral circulation improvement occurred in 12 patients（accounting for31.58%）from the treatment group, and on treatment day 7, the improved cases increased to 16（accounting for 42.11%）. In the control group, 3 cases（7. 89 %） were improved on treatment day 3, and 4（10. 53 %）improved on treatment day 7. The treatment group had better effect on improving collateral circulation than the control group,the difference being significant（P〈0.01）.（2）In the treatment group,9 cases had increased blood flow velocity（Vm）of the responsible vessels on treatment day 3,and 11 cases had the increase on treatment day 7. In the control group, Vm increase occurred in one case both on treatment day 3 and 7. The treatment group had better effect on increasing Vm than the control group,the difference being significant（P〈0.05）.（3）On treatment day 7,NIHSS scores were decreased in both groups（P〈0.05 or P〈0.01）,and the decrease of the treatment group was superior to that of the control group（P〈0.01）.（4）No adverse event was shown in the two g roups during the treatment. Conclusion BHD can constantly improve the blood flow velocity of the responsible vessel and promote collateral vessel building, which results into the recovery of the impaired neural function.
出处
《广州中医药大学学报》
CAS
2016年第1期1-4,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省科技计划项目(编号:2012A030400001)
关键词
急性脑梗死/中药疗法
补阳还五汤
脑侧支循环
acute cerebral infarction / TCD therapy
Buyang Huanwu Decoction
cerebral collateral circulation
