摘要
目的 通过Meta分析了解我国医院发现的社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）的分子生物学特征和流行病学现状。方法 系统检索2015年12月3日前收录于中国知网（CNKI）、万方数据库、PubMed和Web of Science核心合集的期刊或学位论文,遵照PRISMA规范进行Meta分析,利用Stata 13.0软件对医院发现的CA-MRSA检出率、杀白细胞素基因（PVL）基因携带率等数据进行合并,对医院和社区的CA-MRSA检出率进行比较。结果 医院患者中检出的CA-MRSA占金黄色葡萄球菌的12%（95% CI：8%～16%）;占MRSA的18%（95% CI：12%～24%）;CA-MRSA中PVL携带率约为42.1%（95% CI：20.4%～63.7%）,高于一般的MRSA（t=-2.99,P=0.011）。结论 我国医院中CA-MRSA检出率较低,但PVL基因携带率高。需采取有效监测和预防措施,以达到控制CA-MRSA在人群中传播的目的。
Objective To study the molecular-biologic characteristics and epidemiological status of iatrogenic related Community-acquired methicillin-resistant Staphylococcus（S.） aureus（CA-MRSA） in China through Meta-analysis.Methods Data through systematic searching for peer-reviewed articles published before December 3rd, 2015 from 4 main electronic databases including China National Knowledge Infrastructure（CNKI）, Wanfang Data, PubMed and Web of Science Core Collection was collected, for this Meta-analysis.PRISMA guidelines were followed and the proportion of MRSA, CA-MRSA, hospital-acquired MRSA（HA-MRSA） and panton-valentine leucocidin（PVL） gene in certain populations were quantitatively analyzed by Stata 13.0 software.Results Average proportion of CA-MRSA from S.aureus was 12%（95% CI：8%-16%）.CA-MRSA in MRSA was 18%（95% CI：12%-24%）.42.1%（95% CI：20.4%-63.7%） of the CA-MRSA carried a PVL gene, and the number was higher than general MRSA（t=-2.99, P=0.011）.Conclusion CA-MRSA was in lower proportion than HA-MRSA, both seen in general MRSA and in S.aureus, but under higher proportion of carrying the PVL gene.Transmission of CA-MRSA could be prevented within the general population through conducting effective surveillances and preventive programs.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2016年第2期273-280,共8页
Chinese Journal of Epidemiology
关键词
耐甲氧西林金黄色葡萄球菌
社区获得性感染
医院感染
杀白细胞毒素
耐药性
Methicillin-resistant Staphylococcus aureus
Community acquired infection
Nosocomial infection
Panton-valentine leucocidin
Drug resistance
