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雷公藤内酯醇对佐剂性关节炎大鼠脊髓和背根神经节中白细胞介素-1β、肿瘤坏死因子-α表达的影响及其与镇痛的关系 被引量：3

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摘要 目的观察不同剂量雷公藤内酯醇(TP)对佐剂性关节炎(AA)大鼠脊髓背角和背根神经节(DRG)中白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α表达的影响,探讨TP对AA镇痛作用的脊髓神经生物学机制。方法选用SD大鼠50只,随机分成正常组(A组)、模型组(B组)、TP低(C组)、中(D组)、高(E组)剂量治疗组。造模后14 d,C、D、E组大鼠采取不同剂量TP腹腔注射给药,每天1次,连续给药9 d。检测大鼠热痛阈,免疫组化技术检测腰5(L5)脊髓背角和DRG节段中IL-1β、TNF-α的表达变化。结果治疗9 d后,B组大鼠热痛阈显著低于A组(P<0.01),C、D、E组热痛阈显著高于B组(P<0.05,P<0.01),TP可显著提高AA大鼠热痛阈;B组大鼠L5节段脊髓背角和DRG中IL-1β、TNF-α阳性表达水平显著高于A组(P<0.01),C、D、E组大鼠L5节段脊髓背角和DRG中IL-1β、TNF-α阳性表达水平显著低于B组(P<0.01)。结论 TP对RA具有良好镇痛作用;TP可能是通过下调AA大鼠脊髓背角和DRG中IL-1β、TNF-α的表达水平起到镇痛作用。
作者 陈伟 张旭东 逯卓卉 韦登明 林荣
机构地区 宁波大学医学院病理学教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第4期808-810,共3页 Chinese Journal of Gerontology
基金 宁波市药物依赖及共患精神疾病防治创新团队项目(2009B21002) 宁波市自然科学基金项目(2014A610247) 宁波大学学科项目(XKL14D2102)
关键词 雷公藤内酯醇 佐剂性关节炎 镇痛 白细胞介素-1Β 肿瘤坏死因子-Α
分类号 R285.5 [医药卫生—中药学]
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参考文献11

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中国老年学杂志
2016年 第4期

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