摘要
视神经损伤后会引起视网膜节细胞(RGCs)的凋亡和轴突再生困难。基因治疗是近年来治疗视神经损伤的研究焦点,有望成为有效手段之一。其中载体和靶分子是基因治疗的核心,现在应用的载体主要包括非病毒载体和病毒载体两类,选用合适的载体是基因治疗成功的基础;靶分子主要包括神经营养因子、凋亡相关分子、生长抑制因子、信号转导分子等。本文综述了视神经损伤后基因治疗的相关研究进展。
The optic nerve injury induces apoptosis of retinal ganglion cells （ RGCs ） and abortion of axon regeneration. As a focus of recent researches, the gene therapy became one of the effective methods to repair the injured optic nerve, vector and target molecule play a key role in the gene therapy. To choose suitable vector, non-viral vector or viral vector, is the basement of gene therapy; target molecules consist of neurotrophins, apoptosis related molecules, growth inhibitors, signal transduction molecules and so on.
出处
《解剖科学进展》
2016年第1期75-78,82,共5页
Progress of Anatomical Sciences
基金
国家自然科学基金(31271282
31571239)
