摘要
目的探讨垂体零细胞腺瘤（NCA）内皮细胞特异性分子I（ESM-1）表达及其与患者临床、病理特征的关系。方法对自2010年1月至2014年5月在南京军区福州总医院神经外科行经蝶窦入路显微手术切除的46例NCA标本，应用免疫组化染色检测ESM-1表达情况，并分析其与患者年龄（18-45岁16例、≥46岁30例1、性别（男29例，女17例）、肿瘤最大直径（1-3cm34例、≥3cm11例、〈1cm1例）、侵袭性（侵袭性NCA30例，非侵袭性NCA16例1及Ki．67指数（〈3％29例、≥3％17例1等临床、病理特征的关系。结果46例NCA标本中均可观察到血管内皮细胞ESM-1阳性表达，其中高表达（即中度阳性＋强阳性）32例；40例NCA标本中肿瘤细胞ESM-1阳性表达，其中高表达25例；血管内皮细胞和肿瘤细胞间ESM-1高表达率比较差异无统计学意义（P〉O．05）。侵袭性NCA中血管内皮细胞ESM-1高表达率（23／30）显著高于非侵袭NCA（7／16），差异有统计学意义（P〈0．05）；血管内皮细胞ESM-1高表达率在不同年龄、性别、肿瘤最大直径、Ki-67指数分组间比较差异均无统计学意义（P〉0．05）。肿瘤细胞ESM-1高表达率在不同年龄、性别、肿瘤最大直径、Ki-67指数及是否具有侵袭性分组间比较差异均无统计学意义（P〉0．05）。结论血管内皮细胞ESM．1表达可做为评估NCA侵袭性的分子生物学指标之一。
Objective To explore the expression of endothelial cell specific molecule-1 （ESM-1） and its clinical significance in pituitary null cell adenoma （NCA）. Methods Forty-six cases of NCA specimens, collected from resection of pituitary tumor via microscopic transsphenoidal approach in our hospital from January 2010 to May 2014, were chosen in our study; ESM-1 expressions in the NCA specimens was detected by immunohistochemical S-P method, and the relations of expression results with gender （male： 29; female：17）, age （18-45 years old： 16; ≥46 years old： 30）, maximum tumor diameter （1-3 cm： 34; ≥ 3 cm： 11; 〈 1 cm： 1）, invasion state （invasive NCA： 30; non-invasive NCA： 16）, Ki-67 labeling index （〈3%： 29; ≥3%： 17） and pathological features were analyzed. Results ESM-1 expression was observed in endothelial cells and adenoma cells, with positive rates 100% and 86.96% （40/46）; in the endothelial cells, high expression was noted in 32 patients; and in the adenoma cells, high expression was noted in 25 patients; no significant difference of high expression was noted between the two （P〉0.05）. As compared with that ofnoninvasive NCA （7/16）, the high expression of ESM-1 of invasive NCA （23/30） in endothelial cells was significantly increased （P〈0.05）, while the high expression
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2016年第2期140-144,共5页
Chinese Journal of Neuromedicine
基金
南京军区“十二五”医学创新重点项目（20112034）福州总医院创新团队基金（2014-07）
关键词
垂体腺瘤
零细胞腺瘤
内皮细胞特异性分子1
侵袭性
Pituitary adenoma
Null cell adenoma
Endothelial cell specific molecule-l
Invasiveness
