摘要
目的探讨孟鲁司特联合布地奈德治疗儿童哮喘的疗效及对IL-4、IL-8、TNF-α的影响。方法选择2013年11月～2014年11月我院收治的支气管哮喘患者80例作为研究对象,采取随机数字表法随机分为观察组和对照组,每组各40例,两组患者均予平喘、持续低流量吸氧及抗生素控制感染等常规对症治疗。对照组予布地奈德气雾剂。观察组加用孟鲁司特钠,连续治疗14 d。对两组治疗后的疗效进行评价,并比较两组患者治疗前后IL-4、IL-8、TNF-α水平的变化情况。结果观察组患者治疗后的总有效率达95%,对照组患者治疗后的总有效率达75%,两组临床疗效比较,差异具有统计学意义（P〈0.05）。治疗前两组的炎症因子IL-4、IL-8、TNF-α水平比较,组间差异不显著,治疗后两组的炎症因子IL-4、IL-8、TNF-α水平均较治疗前明显下降。且观察组治疗后的炎症因子IL-4、IL-8、TNF-α水平分别较对照组显著降低,差异具有统计学意义（P〈0.05）。结论孟鲁司特联合布地奈德治疗儿童哮喘可以提高疗效,考虑可能与其降低IL-4、IL-8、TNF-α等炎症因子而抑制炎症反应的作用有关。
Objective To evaluate the clinical efficacy of montelukast combined with budesonide in treatment of children with asthma and the influence on IL-4,IL-8,TNF-α. Methods From November 2013 to November 2014 in our hospital,80 patients with bronchial asthma were selected as the research objects,were randomly divided into observation group and control group according to random number table method,each with 40 cases, two groups of patients were treated with asthma,continuous low flow oxygen and antibiotics to control infection and other conventional symptomatic treatment. The control group was treated with budesonide aerosol,the observation group was added with montelukast,continuous treatment 14 d. The efficacy of treatment was evaluated,and the changes of TNF-α,IL-8 and IL-4levels were compared between the two groups before and after treatment. Results The total effective rate of the observation group was 95%,and the total effective rate was 75% in the control group, and the difference was significant（P〈0.05）.Before treatment,the levels of inflammatory factors TNF-α,IL-8 and IL-4 in the two groups were compared,and the differences were not significant. The levels of TNF-α,IL-8 and IL-4 in the two groups were significantly decreased compared with those before treatment. IL-4,IL-8 and TNF-α levels in the observation group were significantly lower than those in the control group,the difference was significant（P〈0.05）. Conclusion Montelukast combined with budes onide in treatment of children with asthma can improve the curative effect,taking into account may be related to decreased IL-4 and IL-8,TNF-α and inflammatory cytokines inhibit the role of inflammatory reaction.
出处
《中国现代医生》
2016年第3期44-46,共3页
China Modern Doctor
