摘要
目的探讨中性粒细胞CD64指数在诊断肿瘤患者感染的临床价值。方法收集败血症患者(血培养阳性)12例,局部临床感染患者(明显的临床感染症状、影像学诊断、临床检测确诊,经抗菌药物治疗后有效)75例,疑似临床感染患者[发热、咳嗽,白细胞计数(WBC)、中性粒细胞数(GR#)上升等,细菌培养阴性,影像学诊断无特异性图像]16例,健康对照者14例,采用流式细胞仪对所有研究对象进行中性粒细胞CD64指数检测,并同时进行血常规、C反应蛋白(CRP)和降钙素原(PCT)检测。结果败血症组患者CD64指数和PCT与局部感染组比较,差异有统计学意义(P<0.05);败血症组和局部感染组CD64指数、WBC、GR#、中性粒细胞数百分比(GR%)、CRP、PCT与健康对照组比较,差异均有统计学意义(P<0.05);疑似感染组CD64指数、WBC、GR%、CRP、PCT与健康对照组比较,差异均有统计学意义(P<0.05)。肺部细菌感染组与肺部真菌感染组各指标比较,差异无统计学意义(P>0.05);感染患者治疗前后CD64指数有所下降,但差异无统计学意义(P>0.05)。CD64指数与PCT呈正相关,而与CRP无相关性。CD64指数诊断败血症的灵敏度为75.0%、特异度为73.0%;PCT敏感度为67.7%、特性度为57.7%。结论 CD64指数诊断优于其他检测指标,有助于败血症的早期诊断并指导临床及时合理运用抗菌药物。
Objective To study the clinical value of the CD64 index in the diagnosis of Clinical infection in tumor patients and to help clinical early and rationally use of antibiotics.Methods Collected in patients with sepsis12cases;partial clinical infection patients 75patients;suspected clinical infection 16 cases and healthy controls 14 cases.The neutrophil CD64 index in these samples were detected by Using flow cytometry and at the same time WBC,C-reactive protein（CRP）and procalcitonin（PCT）were measured.Results The expression of CD64 and PCT in sepsis group were significantly higher than those in local infection group（P〈0.05）;CD64index,the WBC,GR#,GR%,CRP and PCT in the sepsis and local infection group have statistically significantc,ompared with those in healthy control group（P〈0.05）;CD64index,the WBC,GR %,CRP and PCT in suspected infection group have statistically significant,compared with those in healthy control group（P〈0.05）.There was no statistically significant in bacterial pneumonia and mycotic pneumonia;CD64index declined after treatment,but there was no statistically insignificant;CD64index was positively correlated with the PCT and no correlation with CRP.The sensitivity of the CD64 index in the diagnosis of was 75%,and specificity was 73%;PCT sensitivity was 67.7%,specificity was57.7%.Conclusion The CD64 index is better than PCT in the diagnosis of infection to tumer,CD64 index will help in diagnosing the infection of tumor patients.
出处
《检验医学与临床》
CAS
2016年第4期462-465,共4页
Laboratory Medicine and Clinic
