摘要
目的比较不同剂量阿托伐他汀联合丁苯酞治疗急性脑梗死的临床疗效。方法选取内蒙古自治区人民医院2014年2月—2015年2月收治的急性脑梗死患者90例,随机分为常规剂量组和大剂量组,每组45例。两组患者均采用丁苯酞注射液治疗,常规剂量组患者加用常规剂量阿托伐他汀(10 mg/d)治疗,大剂量组患者联合大剂量阿托伐他汀(20 mg/d)治疗,两组患者均治疗14 d。比较两组患者临床疗效,治疗前后中国卒中量表(CSS)评分、Barthel指数评分、血脂指标〔总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)〕及血清超敏C反应蛋白(hs-CRP)水平。结果大剂量组患者临床疗效优于常规剂量组(u=3.062,P=0.002)。两组患者治疗前CSS评分、Barthel指数评分比较,差异无统计学意义(P>0.05);大剂量组患者治疗后CSS评分低于常规剂量组,Barthel指数评分高于常规剂量组(P<0.05)。两组患者治疗前血清TC、TG、HDL-C、LDL-C及hs-CRP水平比较,差异无统计学意义(P>0.05);大剂量组患者治疗后血清TC、TG、LDL-C、hs-CRP水平均低于常规剂量组,血清HDL-C水平高于常规剂量组(P<0.05)。结论相较于常规剂量阿托伐他汀联合丁苯酞,大剂量阿托伐他汀联合丁苯酞治疗急性脑梗死的临床疗效更优,可更有效地减轻患者神经功能损伤,提高患者生活质量。
Objective To compare the clinical effect of different doses of atorvastatin combined with butylphthalide on acute cerebral infarction. Methods A total ofg0 patients with acute cerebral infarction were selected in the People＇s Hospital of Inner Monggol Autonomous Region from February 2014 to February 2015, and they were randomly divided into standard dose group and large dose group, each of 45 cases. Patients of both groups received butylphthalide injection, and patients of standard dose group received extra atorvastatin （10 ng/d）, while patients of large dose group received extra atorvastatin （20 mg/d）, both groups treated for 14 days. Clinical effect, CSS score, Barthel index score, blood lipids index （ including TC, TG, HDL-C, LDL-C ） and serum hs-CRP level before and after treatment were compared between the two groups. Results The clinical effect of large dose group was statistically significantly better than that of standard dose group （ u = 3. 062, P = 0. 002）. No statistically significant differences of CSS score or Barthel index score was found between the two groups before treatment （P 〉0. 05 ） ; after treatment, CSS score of large dose group was statistically significantly lower than that of standard dose group, while Barthel index score of large dose group was statistically significantly higher than that of standard dose group （ P 〈 0.05 ）. No statistically significant differences of serum level of TC, TG, HDL-C, LDL-C or hs-CRP was found between the two groups before treatment （ P 〉 0. 05 ） ; after treatment, serum levels of TC, TG, LDL-C and hs-CRP of large dose group were statistically significantly lower than those of standard dose group, while serum HDL-C level of large dose group was statistically significantly higher than that of standard dose group （ P 〈 0. 05 ）. Conclusion Compared with standard dose of atorvastatin combined with butylphthalide, large dose of atorvastatin combined with butylphthalide has better clinical effect in treating acute cerebral infarction, can more effectively relieve the neurological function impairment and improve the quality of life.
出处
《实用心脑肺血管病杂志》
2015年第12期87-89,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
阿托伐他汀
丁苯酞
疗效比较研究
Brain infarction
Atorvastatin
Butylphthalide
Comparative effectiveness research
