摘要
目的:探讨原发性扩张型心肌病(DCM)患者血浆网膜素-1和脂联素水平变化。方法:连续入选100例DCM患者,其中纽约心功能分级Ⅱ级患者22例为DCM1组,Ⅲ级患者45例为DCM2组,Ⅳ级患者33例为DCM3组;另选45例健康者作为对照组。采用酶联免疫吸附法测定网膜素-1和脂联素水平。结果:DCM患者血浆网膜素-1水平显著低于对照组,差异有统计学意义(P<0.01);亚组分析显示,3组DCM患者网膜素-1水平均显著低于对照组,但DCM各亚组间差异无统计学意义。DCM患者血浆脂联素水平显著高于对照组,差异有统计学意义(P<0.01);亚组分析显示,3组DCM患者脂联素水平均显著高于对照组,且DCM3组脂联素水平显著高于DCM1组。DCM患者血浆网膜素-1水平与左室射血分数(LVEF)显著正相关,与脂联素、NT-proBNP、左室舒张末期内径(LVEDD)显著负相关;DCM患者血浆脂联素与CRP、NT-proBNP显著正相关,与网膜素、空腹血糖、LVEF显著负相关。结论:血浆网膜素-1和脂联素水平的变化与DCM发生发展密切相关。
Objective：To investigate the plasma levels of omentin-1 and adiponectin in patients with dilated cardiomyopathy（DCM）.Method：One hundred consecutive patients diagnosed with DCM and forty-five healthy subjects were enrolled in the present study.Enzyme-linked immunosorbent assay was used to measure omentin-1 and adiponectin levels in the DCM and control groups.Result：The levels of omentin-1 were significantly lower in the DCM group than the control group,whereas the levels of adiponectin were significantly higher in the DCM group than in the control group.Plasma omentin-1 levels were positively correlated with LVEF（R= 0.52,P〈0.01）but negatively correlated with the levels of adiponectin（R=-0.28,P〈0.01）,N-terminal pro-brain natriuretic peptide（NT-proBNP）（R=-0.48,P〈0.01）and LVEDD（R=-0.21,P〈0.05）.Plasma adiponectin levels were positively correlated with the levels of CRP（R= 0.27,P〈0.01）and NT-proBNP（R= 0.33,P〈0.01）but negatively correlated with fasting glucose（R=-0.22,P〈0.05）and LVEF（R=-0.62,P〈0.01）.Conclusion：Omentin-1 and adiponectin were associated with the presence of DCM.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2016年第2期139-142,共4页
Journal of Clinical Cardiology
