摘要
目的探讨阿司匹林与氯吡格雷双联抗血小板治疗与阿司匹林单药抗血小板治疗在老年低危不稳定型心绞痛患者中的疗效与安全性。方法选取2011年1月至2014年12月于我院住院治疗的120例>65岁低危不稳定型心绞痛患者,随机分为单抗组:阿司匹林100 mg,1次/d;双抗组:阿司匹林100 mg+氯吡格雷75 mg,1次/d,观察6月后2组心绞痛缓解情况以及主要不良心血管事件(MACE)和内脏出血事件的发生情况。结果双抗组患者6月后心绞痛缓解率为85.0%,单抗组为83.3%,差异无统计学意义(P=0.762);双抗组患者MACE事件发生率为1.7%,明显低于单抗组的20.0%(P=0.029),双抗组和单抗组内脏出血事件发生率分别为8.3%、5.0%,2组差异无统计学意义(P=0.712)。结论阿司匹林与氯吡格雷双联抗血小板治疗老年低危不稳定型心绞痛患者疗效优于单用阿司匹林,安全性与阿司匹林单抗血小板无明显差异。
Objective To compare the clinical effects and safety of dual antiplatelet therapy（ DAT） with aspirin and clopidogrel and single antiplatelet therapy（ SAT） with aspirin for low-risk unstable angina pectoris（ UAP） in the elderly patients. Methods A total of 120 patients over 65 years with UAP were enrolled and randomly divided into two groups,SAT group and DAT group. And the data of remittent situation of angina,major adverse cardiac events（ MACE）and visceral hemorrhage events were collected in the following 6 months. Results After 6 months,the remittent rate of angina was 85. 0% and 83. 3% in DAT and SAT group respectively,with no significant difference（ P = 0. 762）. The incidence rate of MACE in DAT group was significantly lower than that in SAT group（ 1. 7% vs. 20. 0%,P = 0. 029）.However,no differences were found in the visceral hemorrhage events between the two groups（ DAT vs. SAT： 8. 3% vs.5. 0%,P = 0. 712）. Conclusions DAT with aspirin and clopidogrel shows better effects than SAT with aspirin for UAP in the elderly patients,and shows no significant difference in safety.
出处
《实用老年医学》
CAS
2016年第2期125-127,131,共4页
Practical Geriatrics
