摘要
目的了解耐碳青霉烯类肠杆菌科细菌的临床分布及药物敏感性,为临床治疗提供参考。方法选取2013年1月至2014年12月临床感染患者中分离出的耐碳青霉烯类肠杆菌科细菌66株,采用Vitek 2Compact型全自动微生物分析系统进行细菌鉴定及药敏试验。结果 66株耐碳青霉烯类肠杆菌科细菌的主要菌种有肺炎克雷伯菌41株(62.1%)、阴沟肠杆菌12株(18.2%)、大肠埃希菌10株(15.1%)、产气肠杆菌3株(4.6%)。科室分布以重症监护室(ICU)(48.6%)、急诊重症监护病房(EICU)(15.1%)、神经外科(12.1%)、呼吸重症监护室(RICU)(9.1%)、血液肿瘤内科(6.1%)为主。标本类型中,以痰液最为常见,占75.8%(50/66),其次是分泌物占16.7%(11/66)。66株耐碳青霉烯类药物肠杆菌科细菌对氨苄西林、氨曲南、头孢唑啉、头孢曲松、头孢吡肟、头孢西丁、阿莫西林/克拉维酸及哌拉西林/他唑巴坦的耐药率均较高(>80.0%),对阿米卡星和替加环素的耐药率较低(<51.2%)。结论耐碳青霉烯类药物肠杆菌科细菌存在着严重的多重耐药,临床治疗需根据药敏试验结果选择抗生素。
Objective To investigate the clinical distribution and drug susceptibility of carbapenem-resistant Enterobacteriaceae so as to provide reference for clinical treatment.Methods 66 strains of carbapenem-resistant Enterobacteriaceae isolated from patients with infections during January 2011 and December 2014 were analyzed using Vitek 2Compact type automatic microbial analysis system.Results The main bacterial species of the 66 strains included Klebsiella pneumoniae（41 strains,62.1%）,Enterobacter cloacae（12strains,18.2%）,Escherichia coli（10strains,15.1%）,and Enterobacter aerogenes（3strains,4.6%）,which were isolated from the departments of ICU（48.6%）,emergency intensive care unit（EICU）（15.1%）,neurosurgery（12.1%）,respiratory intensive care unit（RICU）（9.1%）,and Hematology and Oncology（6.1%）.The types of specimens included sputum which accounted for 75.8%（50/66）,followed by secretion,16.7%（11/66）.The 66 strains were highly resistant to Ampicillin,Aztreonam,Cefazolin, Ceftriaxone, Cefepime, Cefoxitin, Amoxicillin/clavulanate and Piperacillin/tazobactam（80.0%）,while the resistance rates to Amikacin and Tigecycline were lower（51.2%）.Conclusion There are serious multiple drug resistance in carbapenem-resistant Enterobacteriaceae.Antibiotics should be selected according to the results of drug sensitivity test in clinical treatment.
出处
《中国微生态学杂志》
CAS
CSCD
2016年第3期312-315,共4页
Chinese Journal of Microecology
关键词
碳青霉烯类
肠杆菌科细菌
分布
耐药性
Carbapenem
Enterobacteriaceae
Distribution
Drug resistance
