摘要
目的探讨银杏达莫注射液对冠心病不稳定性心绞痛（UAP）的治疗效果及其对内皮细胞功能的作用。方法选取2014年3月-2015年3月我院急诊科室门诊或者住院病人中符合入选标准的UAP患者184例,按照随机数字表法分为实验组94例和对照组90例,通过比较两组患者治疗前后西雅图心绞痛量表评分及心电图ST段压低水平判断银杏达莫注射液的治疗效果;同时比较两组治疗前后von Willebrand因子、内皮素和一氧化氮变化规律,探讨银杏达莫注射液对UAP患者内皮功能的作用。结果两组患者经过银杏达莫注射液治疗后西雅图心绞痛量表评分和心电图ST段压低水平均得到好转,差异均有统计学意义（均P〈0.05）;银杏达莫注射液降低了von Willebrand因子和内皮素表达水平,增加了一氧化氮表达水平,与治疗前相比,差异均有统计学意义（均P〈0.05）。结论银杏达莫注射液能通过保护内皮细胞功能,缓解UAP患者症状,同时改善他们的生活质量,疗效显著,可在临床推广应用。
Objective The aim of the present study was to investigate the effect of ginkgo leaf extract and dipyridamole injection on unstable angina pectoris patients and its potential mechanism.Methods 184 patients with UAP were randomly divided into experimental group（94cases）and control group（90cases）.Seattle Anina Questionnaire,level of ST segment depression in electrocardiogram were recorded,serum level of von Willebrand,endothelin and nitric oxide were detected before and after treatment.Results The Seattle Angina table item rating and ECG ST segment depression level of the two groups were improved.Ginkgo leaf extract and dipyridamole injection reduced the von Willebrand factor and endothelial mRNA expression and increased nitric oxide expression level.The difference was statistically significant（P〈0.05）.Conclusion Ginkgo leaf extract and dipyridamole injection can protect endothelial cell function,alleviate the symptoms of unstable angina patients and improve their quality of life.
出处
《西部医学》
2016年第3期361-364,共4页
Medical Journal of West China
基金
四川省中医药管理局科研课题资助(2014B091)
关键词
银杏达莫
冠心病
内皮细胞功能
疗效
Dipyridamole
Coronary heart disease
Endothelial function
Curative effect
