摘要
目的探讨干扰素联合更昔洛韦治疗带状疱疹的临床疗效及对后遗神经痛和IL-6、IL-10的影响。方法选取2014年1月~2015年2月于黑龙江省电力医院治疗的106例带状疱疹患者作为研究对象,随机数字表法分为对照组52例和观察组54例。2组患者均给予止痛等对症治疗。在此基础上,对照组给予更昔洛韦治疗,观察组在对照组基础上联合应用干扰素治疗。观察比较组间带状疱疹临床疗效、后遗神经痛发生率、后遗神经痛患者疼痛评分及炎性因子IL-6、IL-10水平,并于治疗期间观察不良反应发生情况。结果观察组带状疱疹治疗总有效率显著高于对照组（92.6%vs 78.8%,P〈0.05）。治疗后,观察组和对照组后遗神经痛发生率分别为44.4%和50.0%,组间比较差异无统计学意义,而观察组后遗神经痛患者VAS评分低于对照组[（3.5±0.7）分vs（5.8±0.9）分,P〈0.05]。炎性因子方面,与对照相比,观察组治疗后IL-6水平降低[（137.6±32.4）pg/m L vs（340.5±30.6）pg/m L,P〈0.05],IL-10水平升高[（179.3±22.5）μg/m L vs（150.6±24.1）μg/m L,P〈0.05]。治疗期间,2组患者均无严重不良反应。结论干扰素联合更昔洛韦治疗带状疱疹能够显著提高临床疗效,减轻后遗神经痛疼痛程度,且不良反应轻微。
Objective To investigate curative efficacy of interferon in combination with ganciclovir in treatment of herpes zoster and its effects on post herpetic neuralgia and IL-6,IL-10. Methods 106 patients of herpes zoster who received therapy in Heilongjiang electric power hospital from January 2014 to February 2015 were selected as research objects. Those patients were divided into control group（ n = 52） and observation group（ n = 54）by random number table. All patients were given symptomatic treatments,such as analgesia. Besides that,control group was treated with ganciclovir,while observation group was treated with interferon in combination with ganciclovir. Then,the curative efficacy of herpes zoster,incidence of post herpetic neuralgia,pain score of patients with post herpetic neuralgia and levels of inflammatory factors were compared. And during the treatment,adverse reactions were observed. Results After treatment,the total therapeutic efficacy ratio of herpes zoster in observation group and control group was92. 6% and 78. 8% respectively with statistical difference（ P〈0. 05）. And incidence of post herpetic neuralgia in observation group and control group was 44. 4% and 50. 0% respectively with no statistical difference. Score of VAS which reflects pain in observation group after the treatment was statistically lower than that in control group in patients with post herpetic neuralgia（ P〈0. 05）. As to inflammatory factors,in comparison with control group,level of IL-6 in observation group was statistically lower [（ 137. 6 ± 32. 4） pg / m L vs（ 340. 5 ± 30. 6） pg / m L,P〈0. 05] and level of IL-10 was statistically higher [（ 179. 3 ± 22. 5） μg / m L vs（ 150. 6 ± 24. 1） μg / m L,P〈0. 05]. During the treatment,there was no case of severe adverse reaction.Conclusion Interferon in combination with ganciclovir is effective for herpes zoster,which can significantly increase curative efficacy,alleviate pain degree of post herpetic neuralgia with minor adverse reactions.
出处
《中国生化药物杂志》
CAS
2015年第11期55-57,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
国家自然科学基金资助项目(No 30570083)
