摘要
目的探究噻托溴铵应用在支气管扩张伴阻塞性通气障碍患者治疗中的价值。方法海口市第三人民医院于2014年1月~2015年1月收治的支气管扩张伴阻塞性通气障碍患者45例,采用随机对照方法将患者分为对照组（22例）和实验组（23例）,对照组采用常规方法治疗,实验组予以噻托溴铵粉吸入剂治疗,共治疗8周。在治疗前后分别对2组患者肺功能、血气情况进行对比分析,并通过Borg评分（呼吸困难检测）、6 min步行试验（six-minutes walk test,6MWT）及圣乔治呼吸问卷（St.George＇s respiratory questionnaire,SGRQ）对所有患者的总体健康状况进行评估。结果治疗后,实验组每分钟最大通气量（maximal voluntary ventilation,MVV）占预计值%显著高于对照组（P〈0.05）,而肺功能指标1 s用力呼气容积（forced expiratory volume in one second,FEV1）、FEV1占预计值%、用力肺活量（forced vital capacity,FVC）占预计值%、FEV1/FVC比较差异不具统计学意义;实验组Pa CO2显著高于对照组（P〈0.05）,2组间Pa O2比较差异不具有统计学意义;实验组6MWD显著高于对照组（P〈0.05）,实验组SGRQ值显著低于对照组（P〈0.05）。结论长期规律使用噻托溴铵粉吸入剂可改善支气管扩张伴阻塞性通气障碍患者的肺通气功能,改善患者生活质量。
Objective To explore the value of tiotropium bromide in the treatment of patients with bronchiectasis accompanied by obstructive ventilation dysfunction. Methods 45 patients with bronchiectasis accompanied by obstructive ventilation dysfunction who were treated in the third people＇s hospital of Haikou city from January 2014 to January 2015 were selected,and divided into control group（ 22 cases） and experimental group（ 23cases） with the randomized controlled methods. The control group received routine treatment and experimental group received tiotropium bromide powder inhalation for a 8 week＇s consecutive treatment. The pulmonary function,blood gas were compared and analyzed by BORG dyspnea score,six-minutes walk test（ 6MWT） and St. George＇s respiratory questionnaire（ SGRQ）. Results After treatment,maximal voluntary ventilation（ MVV）（ %） in experimental group was significantly higher than that in control group（ P〈0. 05）,but there were no significant differences in forced expiratory volume in one second（ FEV1）,FEV1（ %）,forced vital capacity（ FVC）（ %） and FEV1 / FVC between two groups. The Pa CO2 in experimental group was significantly higher than that in control group（ P〈0. 05）,but there was no significant difference in Pa O2 between two groups. The 6MWD in experimental group was significantly higher and SGRQ values was lower than those in control group（ P〈0. 05）. Conclusion Long-term and regular usage of tiotropium bromide powder inhalation could improve pulmonary ventilation function and improve the quality of life of patients with bronchiectasis accompanied by obstructive ventilation dysfunction.
出处
《中国生化药物杂志》
CAS
2015年第12期150-152,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
支气管扩张
阻塞性通气障碍
噻托溴铵
bronchiectasis
obstructive ventilation dysfunction
tiotropium bromide
