摘要
目的：研究乙肝病毒载量对门静脉压力的影响及其可能分子机制。方法：2014年1月~2015年4月期间收集在重庆市渝北区人民医院治疗的HBsAg阳性的慢性乙型肝炎早、中期肝硬化患者86例,随机分为观察组与对照组2组,对照组予常规治疗,观察组予抗病毒治疗（阿德福韦酯片10 mg,1次/d,疗程6个月）,比较2组治疗前后HBV-DNA、门静脉充血指数及其可能影响因素NO、CO、ET-1（内皮素-1）水平,并采用Logistic回归分析影响门静脉充血指数的影响因素。结果 ：观察组治疗前平均病毒载量lgHBV-DNA（6.42±2.11）,治疗后平均病毒载量lgHBV-DNA（4.38±2.20）,治疗前后相比较差异具有统计学意义（P〈0.05）;对照组治疗前平均病毒载量lgHBV-DNA（6.40±2.08）,治疗后平均病毒载量lgHBV-DNA（5.38±3.31）,治疗前后相比较差异具有统计学意义（P〈0.05）。观察组治疗后与治疗前相比较,PV-CI、ET-1、CO、NO降低,差异均有统计意义（均P〈0.05）;观察组治疗后与对照组相比较,PV-CI、ET-1、CO、NO水平降低,差异亦均有统计学意义（均P〈0.05）;对照组治疗前后相比较,PV-CI、CO、NO、ET-1水平差异无统计学意义（P〉0.05）。多元Logistic回归分析结果显示病程、Child分级、lgHBV-DNA为影响门静脉压力指标PV-CI的危险因素。结论：抗病毒治疗能够减缓HBsAg阳性的慢性乙型肝炎早、中期肝硬化门静脉高压,预防相关严重并发症的进展。
Objective：To investigate the influence of HBV-DNA load on portal venous pressure and its molecular mechanism in HBsAg positive chronic HBV liver cirrhosis.Methods：From January 2014 to April 2015,86 cases of HBsAg positive chronic HBV liver cirrhosis were recruited and divided randomly into two groups as observation group and control.The observation group accepted anti-virus treatment（Adefovir dipivoxil tablet 10 mg qd for 6 months）beside regular liver-protecting therapy.And the control group accepted regular therapy only.The HBV-DNA load by PCR,PV-CI in Colorful Doppler ultrasound and NO,CO,ET-1concentration in serum before and after the treatment were detected and analyzed in SPSS 19.0for windows.Results：After treatment the observation group HBV-DNA load,PV-CI,NO,CO,ET-1were significantly decreased as compared each to that before the treatment and that after treatment in control（P〈0.05）.Further Logistic regression analysis showed that lgHBV-DNA,Child classification,lgHBV-DNA were risk factors of hyperportal venous pressure.Conclusion：Anti-virus therapy in HBsAg positive chronic HBV liver cirrhosis could improve portal venous pressure,which might prevent serious related complications from further developing.
出处
《海南医学院学报》
CAS
2016年第9期857-859,共3页
Journal of Hainan Medical University
基金
重庆市卫生科技计划项目(20112424)~~
关键词
慢性乙型肝炎
肝硬化
门静脉压力
Chronic hepatitis B
Liver cirrhosis
Portal venous pressure
