摘要
目的通过分析桥蛋白(OPN)和Survivin在前列腺癌(PCa)组织中的阳性表达与前列腺特异性抗原(PSA)的相关性分析,探究前列腺癌的预后判断方法。方法检测70例前列腺癌和48例前列腺增生组织应用免疫组织化学方法相关蛋白OPN、Survivin蛋白的表达和相应患者血浆中PSA值。结果前列腺癌组织中OPN和Survivin蛋白的阳性表达率分别51.4%(36/70)、65.7%(46/70),OPN和Survivin在前列腺增生组织中的阳性表达率分别10.4%(5/48)、0(0/48),在前列腺增生和前列腺癌组织组织中OPN和Survivin蛋白阳性表达率差异具有统计学意义(P<0.05),Survivin与OPN在前列腺癌组织中的阳性表达呈负相关(P<0.01)。OPN和Survivin蛋白表达和PSA数值与前列腺癌病理分级、临床分期、转移情况有关,具有统计学意义(P<0.05)。结论在临床上检测OPN、Survivin表达和前列腺特异抗原(PSA),对前列腺癌疾病的预后有作用。
Objective By means of detecting the analysis of the correlation PSA and between expression of OPN and Survivin in prostate cancer tissue we want to investigate the methods of therapy to PCa.Methods Immunohistochemistry was employed to measure the expression of OPN and Survivin cases of prostatic cancer and 48 cases benign prostatic hyperplasia and PSA in plasma.Results In prostatic cancer tissue,the positive expression rates of OPN and Survivin were 51.4%（36/70）、and 65.7%（46/70）.In benign prostatic hyperplasia tissue,the positive expression rates of OPN and Survivin were 10.4%（5/48）、0（0/48）,The positive expression of OPN and survivin between prostatic cancer and benign prostatic hyperplasia were significantly different（P〈0.05）.The positive expression of OPN and survivin were related with the histologic grade,clinical stage and metastasis of prostatic cancer and PSA（P〈0.05）.The expression of survivin was a reverse correlation with OPN expression in prostatic cancer（P〈0.01）.Conclusion The detection expression of OPN and Survivin and PSA in PCa may help to offer a new mode for the prevention and treatment of prostatic cancer.
出处
《中国实验诊断学》
2016年第3期392-395,共4页
Chinese Journal of Laboratory Diagnosis
基金
内蒙古自治区高等学校科学研究项目(NJZY13173)
2015年内蒙古自治区自然科学基金面上项目(2015MS0877)
内蒙古民族大学自然科技基金培育项目(NMDGY1438)
