摘要
目的：探究红藤养胃汤对胃癌患者血清胃癌相关抗原（MG7-Ag）、胃蛋白酶（PG）、组织多肽特异性抗原（TPS）及骨桥蛋白（OPN）表达水平的影响,为胃癌治疗提供依据。方法：将我院2012年4月~2015年4月因胃癌接受治疗的患者90例纳入本研究,均衡分为A、B、C组,每组各30例,A组服用红藤养胃汤进行治疗,B组胃富春片进行治疗,C组则采用西药进行治疗,治疗前及治疗1、2个月后检测各组MG7-Ag、PG、TPS及OPN。结果：治疗前及治疗1、2个月血清MG7-Ag检测,各组治疗后MG7-Ag低于治疗前,差异有统计学意义（P〈0.05）。A组服用红藤养胃汤,治疗后与C、B组MG7-Ag水平比较,差异均无统计学意义（P〉0.05）;治疗1、2个月,A组血清PG水平高于治疗前,并高于B、C组,差异均有统计学意义（P〈0.05）;血清OPN、TPS水平显著低于治疗前,差异有统计学意义（P〈0.05）,A组血清OPN、TPS水平低于B、C组,差异具有统计学意义（P〈0.05）。结论：胃癌患者服用红藤养胃汤后,血清OPN、TPS显著降低,血清PG升高,效果较为显著,患者血清MG7-Ag水平与西药、胃富春片疗效无显著变化,应进一步深入研究。
Objective：To explore hong teng yang wei decoction on patients with gastric cancer serum associated antigen（MG7-Ag）,pepsin（PG）,tissue polypeptide specific antigen（TPS）and osteopontin（OPN）levels,so as to provide the basis for treatment of gastric cancer.Methods：From April 2012 to April 2015,90 cases of patients who received treatment due to gastric cancer were included into the study,and then evenly divided into group A,group B,group C,with 30 cases of each group.Group A patients took hong teng yang wei decoction treatment,while group B took Wei fu chun tablets treatment,and group C took western medicine treatment.MG7-Ag,PG,TPS and OPN levels were detected before treatment and 1and 2months after treatment.Results：After treatment,the serum MG7-Ag levels of patients in all groups were significantly lower than those before treatment（P〈0.05）and there is no significant differences between group A with patients taking Yangwei decoction and group B,C（P〉0.05）.One and two months after treatment,the serum PG levels of group A were significantly higher than that before treatment,and of group B and C as well（P〈0.05）.After treatment,the serum levels of OPN and TPS levels were significantly lower than that before treatment（P〈0.05）,and the serum OPN and TPS levels of group A were significantly lower than that of group B and C（P〈0.05）.Conclusion：For patients with gastric cancer,hong teng yang wei decoction,can significantly decrease serum levels of OPN and TPS And increase serum PG level with great effect.However,in terms of efficacy on serum MG7-Ag level,hong teng yang wei decoction does not show significant difference when compared to the western medicine,stomach fu kang tablets,which need further in-depth study.
出处
《海南医学院学报》
CAS
2016年第10期996-998,1002,共4页
Journal of Hainan Medical University
基金
江苏省卫生厅重点学科省内开放课题(KF201312)~~
