摘要
目的 本研究主要探讨血浆BNP水平对心血管患者远期病死率及预后的影响.方法 对笔者医院2003年5月~2005年2月期间住院的患者,共276例,失访2例,随访7年,根据BNP水平分为BNP〈100ng/L、101~1000ng/L、1001~5000ng/L、〉5000ng/L 4组,比较各组间病死率,绘制生存曲线.结果 随访期间,91例患者死亡,其中心源性死亡50例,非心源性死亡41例.4组比较,各组间病死率比较差异有统计学意义（P=0.000）,随BNP浓度的增加,病死率逐渐升高.在多因素比较中,BNP、年龄和EF值差异均有统计学意义（P〈0.05）,BNP是影响患者预后的独立危险因素,BNP〉5000ng/L组,3个月的病死率为超过50%,5年的病死率为100%.结论 BNP水平是影响病死率的一个独立危险因素,BNP〉5000ng/L,近期及远期预后均严重不良.
Objective To explore the effeclt of brain natriuretic peptide（BNP） of long-term mortality and prognostic value in patients with cardiovascular diseases. Methods A total of 276 patients with cardiovascular diseases were enrolled, and followed up for 7 years. They were divided into three groups according to the level of plasma BNP： BNP〈100ng/L; group 2, 101-1000ng/L; 1001-5000ng/L;group 4, BNP〉5000ng/L. All causes of mortality were examined in relation to BNP levels during follow up. COXregression was used to assess the relevance of baseline characteristics to risk of death. Results All cause death occurred in 91（33%） subjects. Higher levels of plasma BNP were related to higher mortality. COX regression showed BNP was significantly associated with a increased risk for all-cause mortality（P=0.000）. In group 4, the mortality was 53.8% in three months and 100% in five years follow up. Conclusion BNP is a biochemical marker of increased risk of long-term all-cause mortality in patients with cardiovascular diseases.
出处
《医学研究杂志》
2016年第3期138-141,共4页
Journal of Medical Research
关键词
脑钠素
心力衰竭
病死率
心血管疾病
Brain natriuretic peptide
Heart failure
Mortality
Cardiovascular diseases
