摘要
目的探讨尤瑞克林治疗急性脑梗死的临床疗效及其对相关促/抑炎性因子水平的影响。方法选取72 h内发病的轻度到中度急性脑梗死患者40例,随机分为常规治疗组和尤瑞克林组各20例,健康成年人20例为正常组。各组分别在住院1 d及14 d进行NIHSS评分;并测定血浆中IL-1β、IL-6、IL-10、IL-8和MCP-1的动态变化。结果两组患者基线特征一致。两组患者NIHSS评分在治疗前无统计学差异;治疗后尤瑞克林组和常规治疗组NIHSS评分均显著低于治疗前,且尤瑞克林组较常规治疗组更明显(P<0.05)。住院1 d时,尤瑞克林组、常规治疗组IL-1β、IL-6、IL-8和MCP-1水平均显著高于正常组(P<0.05);治疗14 d后尤瑞克林组患者血浆中IL-1β、IL-6、和MCP-1水平较住院1 d时显著降低(P<0.05),IL-10的浓度则显著升高(P<0.05);而常规治疗组患者血浆中各相关促/抑炎性因子水平较住院1 d时无统计学差异。结论在急性脑梗死的发病中,多种促/抑炎性因子发挥了重要的作用;尤瑞克林显示出了显著的减轻脑损伤作用;通过抑制IL-1β、IL-6、和MCP-1的表达,上调IL-10表达,调节免疫反应强度可能是其发挥神经保护作用的重要机制之一。
Objective To explore the effect of urinary kallikrein injection on patients with acute ischemic stroke and the variation of IL-1β,IL-6,IL-8,IL-10 and MCP-1 in the plasma of patients suffering from ischemic stroke. Methods Forty cases who came from the second hospital of Hebei medical university suffering from cerebral infarction between 6 and72 h of onset were randomly assigned into the conventional group（ n = 20） and kallikrein group（ n = 20）. The conventional group was given conventional treatment,whereas the kallikrein group was given both conventional treatment and urinary kallikrein injection over the course of 14 days. The NIHSS score was evaluated before and after treatment. The concentration of IL-1β,IL-6,IL-8,IL-10 and MCP-1 were tested by ELISA respectively at 1 and 14 days after stroke onset. Results（ 1）General information： There were totally 40 cases meeting the criteria patients including 20 cases of conventional group and20 cases of kallikrein group. There was no difference in the general situation such as age,gender,concomitant disease,time between onset and healing NIHSS score before healing（ P〈0. 05）.（ 2） The NIHSS scores in the two groups were not statistically different before treating,statistical differences emerged after treating between two groups. The improvement of NIHSS score in the kallikrein group was greater than the conventional group（ P〈0. 05）. And the adverse reaction rates in the two groups were not statistically different.（ 3） The concentration of IL-1β、IL-6、IL-8、MCP-1 and IL-10 in the plasma in three groups： comparing to the health group,the concentration of IL-1β,IL-6,IL-8,MCP-1 and IL-10 were significantly increased in kallikrein group and conventional group（ P〈0. 05）; comparing to conventional group,the concentration of IL-1β,IL-6,and MCP-1 were greatly decreased in kallikrein group（ P〈0. 05）; Comparing to conventional group,the concentration of IL-10 was significantly increased in kallikrein group（ P〈0. 05）. Conclusions（ 1） Urinary kallikrein showed a relatively conclusive effect on the improvement of cerebral functions in patients with acute cerebral infarction.（ 2） Urinary kallikrein could decrease the expression of IL-1β,IL-6,IL-8 and MCP-1 and upregulate the expression of IL-10 at the same time in patients. The immune-modulated effect of Urinary kallikrein may be achieved by the activation of IL-1β,IL-6,MCP-1 and IL-10.
出处
《中风与神经疾病杂志》
CAS
北大核心
2016年第3期219-221,共3页
Journal of Apoplexy and Nervous Diseases
基金
河北省科技厅科技攻关计划(04276101D-16)
河北省卫生计生委研究课题(20130181)
关键词
尤瑞克林
急性脑梗死
炎症反应
细胞因子
Urinary kallikrein
Acute cerebral infarction
Inflammation
Cytokine
