摘要
鉴别单双相抑郁是临床上的一个重要挑战,综述近年来脑影像学在鉴别单相抑郁和双相抑郁方面的发展,寻找识别双相障碍的生物学标志,以利于更好的优化临床决策。检索Pubmed、万方、中国知网等数据库,选取“单相抑郁”或“重性抑郁症”、“双相抑郁”、“磁共振成像”“模型”等为检索词。目前直接比较单双相的结构及功能影像学研究均很少,大部分研究提示双相障碍较单相抑郁的脑损害更重,其脑结构及功能环路损害涉及不同脑区,影像学特征建模识别两组疾病的准确率较高。需要更多的直接比较单双相障碍的脑影像学研究,影像学作为客观的生物学鉴别标志是一个可行的研究领域。
Differentiating bipolar disorder (BD) from unipolar depression (UD) is an important clinical challenge.Review the development of Magnetic Resonance Imaging ( MRI) in distinguishing the BD and UD, identifying objective markers of BD, to optimize clinical decision making.Database including PubMed,Wan Fang,CNKI and so on.The key words were used"unipolar depression"or"major depressive depression","bipolar depression","MRI","model"and so on.A little neuroimaging studies to date have directly compared UD and BD depressions.Most results from these studies suggest more heavy neural circuit abnormalities in BD than UD depression,involved in different brain regions.Predictive models based on neu-roimaging characteristics of BD and UD obtain a higher accuracy and can help differentiate BD from UD.This review serves as a call to highlight the need for more neuroimaging studies to compare individuals with BD depression with individuals with UD depression directly.Using neuroimaging results as objective biological i-dentification markers is a feasible research field.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2016年第3期276-279,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家高技术研究发展计划(2015AA020509)
国家自然科学基金(81571639,81371522,61372032)
江苏省自然科学基金(BK20131074)
江苏省临床医学科技专项(BL2014009)
关键词
单相抑郁
双相抑郁
磁共振成像
Unipolar depression
Bipolar depression
Magnetic resonance imaging