摘要
目的探讨老年原发性高血压患者记忆障碍及其危险因素。方法选择2013年1月至2014年12月在咸宁市中心医院接受治疗的老年原发性高血压患者152例为研究对象,采用简易精神状态检查表(MMSE)评估患者的认知功能,采用行为记忆测验法第2版(RBMT-Ⅱ)评定患者的记忆功能,采用Pearson线性相关性检验分析记忆障碍患者收缩压(SBP)、脉压(PP)与MMSE、RBMT-Ⅱ评分的相关性,采用logistic回归分析方法分析高血压患者记忆障碍的危险因素。结果 152例患者中发生记忆障碍80例(观察组),无记忆障碍72例(对照组)。观察组患者定向力、短时记忆评分及总评分显著低于对照组(P<0.05),2组患者即刻记忆、注意力和计算能力、语言能力评分比较差异无统计学意义(P>0.05)。高血压Ⅲ级患者的MMSE评分、RBMT-Ⅱ评分均显著低于高血压Ⅰ、Ⅱ级患者(P<0.05),高血压Ⅱ级患者的RBMT-Ⅱ评分显著低于高血压Ⅰ级患者(P<0.05)。观察组患者SBP、PP与RBMT-Ⅱ评分呈负相关(r=-0.403,-0.348,P<0.05),SBP与MMSE评分呈负相关(r=-0.224,P<0.05)。Logistic回归分析显示,高SBP和PP水平是老年原发性高血压患者记忆障碍的独立危险因素(P<0.05)。结论老年原发性高血压患者可出现记忆障碍,患者血压水平越高,记忆障碍越严重;高水平的SBP和PP是老年原发性高血压患者记忆障碍的独立危险因素。
Objective To study the risk factors for memory disorders in elderly patients with primary hypertension.Methods A total of 152 elderly patients with primary hypertension were selected from January 2013 to December 2014 in Xianning Central Hospital. The cognitive function of the patients was evaluated by mini-mental state examination（ MMSE）,the memonic function of the patients was evaluated by the rivermead behavioral memory test second edition（ RBMT-Ⅱ）. The correlation of systolic blood pressure（ SBP）,pulse pressure（ PP） and MMSE,RBMT-Ⅱ score in patients with memory disorders were analyzed by Pearson linear correlation test. The risk factors of memory disorders in patients with primary hypertension were analyzed by logistic regression analysis. Results There were 80 patients with memory disorder（ observation group） among 152 patients,72 patients without memory disorder（ control group）. The orientation score,short-term memory score and total score in observation group were significantly lower than those in control group（ P 〈0. 05）. There was no significant difference in the scores of immediate memory,attention and computational ability,linguistic capacity between the two groups（ P 〈0. 05）. The MMSE score and RBMT-Ⅱ score in patients with grade Ⅲ hypertension were significantly lower than those in patients with gradeⅠ- Ⅱ hypertension（ P 〈0. 05）. The RBMT-Ⅱ score in patients with grade Ⅱ hypertension was significantly lower than that in patients with grade Ⅰ hypertension（ P 〈0. 05）. In observation group,SBP and PP were negatively correlated with RBMT-Ⅱ score（ r =- 0. 403,- 0. 348,P 〈0. 05）,SBP was negatively correlated with MMSE score（ r =- 0. 224,P 〈0. 05）. Logistic regression analysis showed that high SBP and PP were independent risk factors for memory disorder in elderly patients with primary hypertension（ P 〈0. 05）. Conclusions Memory disorder can occur in the elderly patients with primary hypertension. With the increase of blood pressure,the memory disorder is more serious. High SBP and PP are independent risk factors for memory disorder in elderly patients with primary hypertension.
出处
《新乡医学院学报》
CAS
2016年第3期212-214,共3页
Journal of Xinxiang Medical University
