摘要
目的目前，调强放射治疗技术已被广泛应用于鼻咽癌的治疗中，本研究旨在探讨同步推量调强放射治疗与传统调强放疗治疗在鼻咽癌患者的近期和远期治疗效果。方法选取2008—04—12—2010—07—01山东省肿瘤医院收住的鼻咽癌患者102例，根据放疗方式不同分为研究组（50例）和对照组（52例）。研究组采用同步推量调强放疗，对照组采用传统调强放疗，比较两组的近期有效率、毒副作用和远期疗效。结果两组总有效率分别为90．0％（45／50）和86．5%（45／52）；其近期疗效差异无统计学意义，x2=0．022，P=0．882；研究组和对照组3～4级口腔黏膜急性毒副作用分别为54．0％和55．8％（P=0．858），面颈部皮肤反应分别为4．0％和11．5％（P=0．245）；两组5年无进展生存率、总生存率分别为76．0％和69．2％（x2=1．14，P=0．286）和84．0％、82．7％（x2=0．031，P=0．859）。结论与传统调强放疗相比，同步推量调强放疗在鼻咽癌近期和远期疗效及副作用方面的效果相似，两者差异无统计学意义。
OBJECTIVE Urrently the intensity modulated radiotherapy （IMRT） technique has been widely applied to the treatment of nasopharyngeal earcinoma（NPC）, the study aimed to investigate the therapeutic effects comparing simultaneous integrated boost （SIB-IMRT） versus conventional intensity modulated radiotherapy （C-IMRT） in patients with NPC. METHODS 102 newly diagnosed local/regional advanced NPC patients were randomized to be treated by SIB-IMRT （n=50） and C-IMRT （n=52） between April 12,2008 and July 1, 2010 in Shandong tumor hospital. The acute radiation toxicities were evaluated by toxicity criteria of the Radiation Therapy Oncology Group （RTOG）. Five-year local control rates, distant metastasis-free survivals and overall survivals were analyzed by the Kaplan-Meier method. RESULTS The overall reponse rate was 90.0%（45/50） and 86.5%（45/52） in two groups, respectively, and the difference of short-term effects was no statistically significant, x2= 0. 022, P = 0. 882. With median follow-up time of 69 months, there was no significant difference in toxicities between the two IMRT techniques. The grade 3-4 acute mucositis and skin reaction of face and neck were 54.0% and 55.8% （P=0. 858）, 4.0% and 11.5% （P=0. 245）. The five-year dis- tant metastasis-free survivals （DMFS） and the overall survivals （OS） were 76.0% and 84.0% in SIB-IMRT and 69.2% and 82.7% in C-IMRT, respectively （P=0. 286 for DMFS and 0. 859 for OS）. CONCLUSION The treatment comparing SIB-IMRT versus C-IMRT was similar and showed no statistically significant differences in terms of the short and long-term effects and the acute adverse events.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2016年第4期244-247,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
鼻咽癌
同步推量调强放疗
传统调强放疗
疗效
nasopharyngeal carcinoma
simultaneous integrated boost-intensity modulated radiotherapy
conventional intensity modulated radiotherapy
efficac
