摘要
目的:探讨鼠神经生长因子修复老年电烧伤患者神经损伤的临床疗效。方法:78例老年电烧伤患者按照随机数字表法分为试验组(40例)和对照组(38例)。两组患者均给予抗感染、改善微循环等常规治疗,在此基础上对照组患者肌内注射维生素B12,每次500μg,qd;试验组患者肌内注射鼠神经生长因子,每次18μg,qd,两组均4周为1个疗程,共治疗2个疗程。比较两组患者治疗前后神经功能评分、神经传导速度的差异;观察两组患者的临床疗效及不良反应发生情况。结果:治疗前,两组患者的针刺觉评分、轻触觉评分、运动评分、感觉神经传导速度与运动神经传导速度比较,差异均无统计学意义(P>0.05)。治疗后,试验组患者的针刺觉、轻触觉与运动评分均较治疗前及对照组显著提高,感觉神经传导速度与运动神经传导速度均较治疗前及对照组显著加快,差异具有统计学意义(P<0.05)。试验组患者的总有效率为92.5%,显著高于对照组(63.2%),差异具有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:肌内注射鼠神经生长因子修复老年电烧伤患者的神经损伤,不仅能够提高其神经功能评分,加快其神经传导速度,还能够提高整体临床疗效。
OBJECTIVE：To explore clinical efficacy of mouse nerve growth factor to repair nerve damage in elderly electrical burn patients. METHODS：78 elderly electrical burn patients were randomly divided into experimental group（40 cases）and control group（38 cases）. Both group received routine treatment,such as anti-infection and improve microcirculation etc;control group was additional given Vitamin B12 intramuscularly,500 μ g each time,qd;experimental group was additional given mouse nerve growth factor,18 μg each time,qd;a treatment course lasted for 4 weeks,and both received 2 courses of treatment. The difference of neurological function score and nerve conduction velocity were compared between 2 groups before and after treatment;clinical efficacy and the occurrence of ADR were observed in 2 groups. RESULTS：Before treatment,there was no statistical significance in pinprick score,light touch score,sports scores,sensory nerve conduction velocity and motor nerve conduction velocity between 2 groups（P〉0.05）. After treatment,pinprick score,light touch score and sports scores of experimental group improved significantly compared to before treatment and control group,and sensory nerve conduction velocity and motor nerve conduction velocity increased significantly compared to before treatment and control group,with statistical significance（P〈0.05）. Total effective rate of trial group was 92.5%,which was higher than that of control group（63.2%）,with statistical significance（P〈0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS：Intramuscular injection of mouse nerve growth factor to repair nerve damage in elderly electrical burn patients can not only improve neurological function score and nerve conduction velocity,but also can improve the clinical efficacy.
出处
《中国药房》
CAS
北大核心
2016年第11期1513-1515,共3页
China Pharmacy
基金
河北省医学科学研究重点课题(No.20130273)
关键词
鼠神经生长因子
电烧伤
老年患者
神经损伤
神经功能评分
神经传导速度
临床疗效
Mouse nerve growth factor
Electrical burns
Elderly patient
Nerve injury
Neurological function score
Nerve conduction velocity
Clinical efficacy
