摘要
目的探讨云南地区非卧床持续腹膜透析(CAPD)患者发生心脑血管事件的危险因素.方法收集云南省不同地区医院1 a内就诊的270例CAPD患者,进行12个月的随访,按有无心脑血管事件发生分成未发生心脑血管事件组(178例)和发生心血管事件组(92例),对比分析2组患者的人口学调查资料、临床资料、生化指标等,采用Logistic回归分析进行统计学处理.结果 2组患者在年龄、性别、学历程度、原发病、透析龄、血清尿素氮(BUN)和血清肌酐(Scr)方面并无差异(P>0.05).发生心脑血管事件组患者在血红蛋白(Hb),总KT/V水平方面均低于未发生心脑血管事件组(P<0.05),而血磷,全段甲状旁腺激素(i PTH),总胆固醇(TG),低密度脂蛋白胆固醇(LDL-C),高敏C反应蛋白(hs CRP)水平方面均高于无心脑血管事件组(P<0.05).结论云南地区CAPD患者发生心脑血管事件与多因素有关,其中血压控制情况、血清总胆固醇水平、低密度脂蛋白胆固醇水平是心脑血管事件发生的重要危险因素.
Objective To analyze the risk factors for cardiovascular event in patients with continuous ambulatory peritoneal dialysis（CAPD） in Yunnan. Me thods 270 cases of CAPD patients were collected during the period from October 2012 to September 2013 in designated hospital in Yunnan. Among all the cases, no cardiovascular or cerebrovascular events occurred in 178 patients, while another 92 patients developed cardiovascular or cerebrovascular events during 12 months follow- up,multiple demographics,clinical indexes and biochemical indicators of patients in both groups were analyzed. The logistic regression analysis was used to analyze the risk factors for adverse cardiovascular events. Re s ults There was no significant difference in gender, age,educational background, primary disease,dialysis age, blood urea nitrogen and serum creatinine between event group and non- event group（P〉0.05）. The levels of serum phosphorus, serum intact parathyroid hormone（i PTH）, serum total cholesterol, low- density lipoprotein cholesterol（LDL- C）, high- sensitivity C- reactive protein（hs- CRP） of event group were higher than those of non- event group, while blood pressure control rates and hemoglobin level of event group were lower than those of non- event group.Conclus ion Blood pressure control rates and the levels of serum total cholesterol,LDL- C are important risk factors for adverse cardiovascular events in CAPD patients.
出处
《昆明医科大学学报》
CAS
2016年第4期95-98,共4页
Journal of Kunming Medical University
基金
云南省应用基础研究基金资助项目(2012FB047)
云南省卫生厅内设研究机构科研项目(2014NS106)
关键词
慢性肾脏病
非卧床持续腹膜透析
心脑血管事件
Chronic kidney disease
Continuous ambulatory peritoneal dialysis
Cardiovascular events
